Arterial Disorders

1. Front Matter

   Pages i-ix

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2. Introductory Aspects

   1. Front Matter

      Pages 1-1

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   2. Definition and Epidemiology of Arterial Disease

      • Reza Aghamohammadzadeh, Danielle Ormandy, Anthony M. Heagerty

      Pages 3-12

   3. Overview of the Normal Structure and Function of the Macrocirculation and Microcirculation

      • Wilmer W. Nichols, Kevin S. Heffernan, Julio A. Chirinos

      Pages 13-46

3. Classification and Clinical Manifestations of Arterial Disease

   1. Front Matter

      Pages 47-47

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   2. Atherosclerosis

      • Michael Hristov, Christian Weber

      Pages 49-55

   3. Arteriosclerosis/Large Artery Disease

      • Michael F. O’Rourke

      Pages 57-68

   4. Vascular Changes in the Microcirculation: Arterial Remodeling and Capillary Rarefaction

      • Carmine Savoia, Ernesto L. Schiffrin

      Pages 69-79

4. Pathogenetic Mechanisms in Arterial Disease

   1. Front Matter

      Pages 81-81

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   2. Perinatal Programming of Cardiovascular Disease

      • Maria Franco

      Pages 83-91

   3. Hemodynamic and Mechanical Factors Acting on Arteries

      • Pierre Boutouyrie, Hélène Beaussier, Stéphane Laurent

      Pages 93-99

   4. Role of Metabolic Factors: Lipids, Glucose/Insulin Intolerance

      • Guanghong Jia, Annayya R. Aroor, James R. Sowers

      Pages 101-113

   5. Biomarkers of Vascular Inflammation and Cardiovascular Disease

      • Paul Welsh, David Preiss, Sofia Tsiropoulou, Francisco J. Rios, Adam Harvey, Maria G. Dulak-Lis et al.

      Pages 115-136

   6. Neurohormonal Interactions

      • Gino Seravalle, Guido Grassi

      Pages 137-150

   7. Arterial Interactions with Mineral and Bone Disorders

      • Gérard M. London

      Pages 151-160

   8. Endothelial Function in Health and Disease

      • Arno Greyling, Maria T. Hopman, Dick H. J. Thijssen

      Pages 161-173

   9. Pharmacologic and Environmental Factors: Coffee, Smoking, and Sodium

      • Charalambos Vlachopoulos, Panagiota Pietri, Dimitrios Tousoulis

      Pages 175-186

5. Systemic Arterial Disorders

   1. Front Matter

      Pages 187-187

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   2. Arterial Ageing

      • Peter M. Nilsson

      Pages 189-202

   3. Renal Arterial Aging

      • Adel E. Berbari, Najla A. Daouk, Samir G. Mallat

      Pages 203-220

As our knowledge about arterial disease is greatly expanding, the aim of this book is to explore all aspects of arterial pathology, including classification, clinical manifestations, pathogenesis, and therapeutic options. The discussion of pathophysiologic mechanisms of arterial disease is wide ranging, encompassing hemodynamic, metabolic, humoral, inflammatory, genetic and environmental factors. Particular emphasis is placed on recent concepts, such as: the role of age-associated arterial alterations in the initiation and progression of cardiovascular diseases in older persons, the importance of mineral metabolism-bone vascular interactions, the clinical and prognostic significance of the renal resistive index, retinal circulation, toxemia of pregnancy as an arterial disease, and the role of pulmonary/vascular interaction in pulmonary hypertension and cross-talk of macrocirculation and microcirculation in target organ involvement. Evaluation procedures are carefully explained, and the full range of currently available therapeutic options, including lifestyle modifications and pharmacologic approaches, are described and appraised. ​  

• Arterial ageing
• Calcium phosphorus and bone metabolism
• Macro-/microcirculation cross-talk
• Renal resistive index
• Toxemia of pregnancy

“This book defines and examines the pathophysiological mechanisms of arterial disorders. … Although intended primarily for general physicians, basic scientists, and physiologists who manage cardiovascular disorders, the book is also useful for internists and medical trainees. … The book includes a comprehensive reference list, color pictures, diagrams, and tables.” (Dustin Y. Yoon, Doody's Book Reviews, May, 2015)

• American University of Beirut Medical Center, Beirut, Lebanon

  Adel Berbari

• University of Milano Bicocca IRCCS Istituto Auxologico Italiano, Milan, Italy

  Giuseppe Mancia

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