MicroRNA Targeted Cancer Therapy

1. Front Matter

   Pages i-x

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2. The Therapeutic Role of MicroRNAs in Human Gliomas

   • Sanila H. Sarkar, Aamir Ahmad, Sandeep Mittal

   Pages 1-27

3. miRNA Expression and Functions in Glioma and Glioma Stem Cells

   • Chaya Brodie, Efrat Buchris, Hae Kyung Lee

   Pages 29-49

4. The Role of MicroRNA in Lung Cancer Drug Resistance and Targeted Therapy

   • Zhaohui Gong, Zhuo Dong, Lihua Yang, Jie Yang, Jingqiu Li, Yanping Le et al.

   Pages 51-82

5. The Potential Role of MicroRNA-Based Therapy for Lung Cancer Stem Cells

   • Yu Fujita, Kazuyoshi Kuwano, Takahiro Ochiya

   Pages 83-98

6. miRNA Targeted Therapy in Lung Cancer

   • Aamir Ahmad, Kevin R. Ginnebaugh, Yiwei Li, Bin Bao, Shirish M. Gadgeel, Fazlul H. Sarkar

   Pages 99-114

7. miRNA-Based Ovarian Cancer Diagnosis and Therapy

   • Rong Guo, Cheryl Sherman-Baust, Kotb Abdelmohsen

   Pages 115-127

8. Application of MicroRNA in the Treatment and Diagnosis of Cervical Cancer

   • Kouji Banno, Miho Iida, Megumi Yanokura, Iori Kisu, Kanako Nakamura, Masataka Adachi et al.

   Pages 129-137

9. Overcoming Drug Resistance in Colorectal Cancer by MicroRNAs

   • Yingjie Yu, Pratima Nangia-Makker, Adhip P. N. Majumdar

   Pages 139-155

10. MicroRNAs as Novel Targets in Liver Cancer: Facing the Clinical Challenge

    • Jens U. Marquardt, Peter R. Galle

    Pages 157-174

11. MicroRNA Based Therapeutic Strategies for Cancer: Emphasis on Advances in Renal Cell Carcinoma

    • Shahana Majid, Rajvir Dahiya

    Pages 175-188

12. Modulating MicroRNA Expression for the Therapy of Pancreatic Cancer

    • Marion Gayral, Yannick Delpu, Jérôme Torrisani, Pierre Cordelier

    Pages 189-197

13. MicroRNA Targeted Therapy for Overcoming Drug Resistance, Reversal of EMT and Elimination of Cancer Stem Cells in Prostate and Pancreatic Cancer

    • Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, Fazlul H. Sarkar

    Pages 199-217

14. Modulation of Deregulated MicroRNAs for Target Therapy in Thyroid Cancer

    • Cesar Seigi Fuziwara, Edna Teruko Kimura

    Pages 219-237

15. miRNA-Targeted Therapies in the Most Prevalent Pediatric Solid Tumors

    • Josep Roma, Ana Almazán-Moga, José Sánchez de Toledo, Soledad Gallego, Miguel F. Segura

    Pages 239-263

16. Targeting Immune System Through Targeting miRNA for Cancer Therapy

    • Hong YuWH, Daniel SzeMY, William ChoCS, YipSP

    Pages 265-287

17. miRNA Regulation of DNA Damage Repair Proteins in Cancer Cells: Interplay of ATM, TRAIL and miRNA

    • Ammad Ahmad Farooqi

    Pages 289-307

18. miRNA Regulation of VEGF/VEGFR Signaling

    • Ammad Ahmad Farooqi, Ilhan Yaylim

    Pages 309-325

19. Systems Biology Approaches in the Design of Effective miRNA-Targeted Therapeutics

    • Ramzi M. Mohammad, B. Bao, Fazlul H. Sarkar, Philip A. Philip, Asfar S. Azmi

    Pages 327-337

20. Back Matter

    Pages 339-351

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Since the discovery of microRNAs (miRNAs) some twenty years ago by Victor Ambros, David Baulcombe and Gary Ruvkun, these three scientists worked to uncover the mystery of miRNA, the small segments of nucleotides that silence genes. While studying the development of the nematode worm, Ambros and Ruvkun discovered miRNA in animals, while Baulcombe discovered it in plants. Since their discovery, it took more than two decade to fully appreciate the value of miRNA in human health and diseases. Emerging evidence suggest that the activation of oncogenes and/or the inactivation of tumor suppressor genes contribute to the development and progression of tumors. The regulation of genes is by far controlled by many transcription factors which are often deregulated during the development and progression of cancer. In addition, emerging evidence clearly suggests that the deregulation of miRNAs or small non-coding RNAs could also regulate the expression of genes and likewise, miRNA genes are also regulated by transcription factors. The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass. Therefore, miRNA targeted therapy is an attractive attribute of miRNA research, which is covered through eighteen chapters complied in this book “MicroRNA targeted Cancer therapy” and it is hoped that the field of miRNA research will be appreciated through critical reading of these chapters on the cutting-edge research on miRNAs.

• Cancer Therapy
• Drug Resistance
• Solid Tumors
• Targeted Therapy
• microRNA

• Pathology, Wayne State University School of Medicine, Detroit, USA

  Fazlul H. Sarkar

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