Overview
- Examines the structural diversity of the Fc domain for IgG and IgE
- Explores the role of Fc receptors in the context of infectious, autoimmune, and neoplastic disorders
- Provides comprehensive information on Fc receptor pathways as an essential part of the immune response
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 423)
Access this book
Tax calculation will be finalised at checkout
Other ways to access
Table of contents (7 chapters)
-
Front Matter
Keywords
About this book
This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins by discussing evolutionary aspects of how the family of Fc receptors that are the key molecules for antibody activity evolved. In turn, it addresses the molecular and cellular pathways underlying IgG activity in cancer immunotherapy, and focuses on how IgG glycosylation regulates IgG and IgE activity in autoimmunity, allergy and infection. In closing, it presents strategies for developing novel antibody-based vaccination approaches. The book is intended for a very broad readership, including graduate students, postdocs and principal investigators with a basic grasp of immunology.
Editors and Affiliations
About the editors
Jeffrey V. Ravetch
Theresa and Eugene M. Lang Professor
Department Leonard Wagner Laboratory of Molecular Genetics and Immunology
Rockefeller University
1230 York Avenue, Box 98
New York, NY 10021, USA
ravetch@mail.rockefeller.edu
Falk Nimmerjahn
Professor for Immunology and Genetics
Chairman of the Institute of Genetics
Head of the Department of Biology
Department of Biology
University of Erlangen-Nuernberg
Erwin-Rommelstr. 3
91058 Erlangen, Germanyfalk.nimmerjahn@fau.de
Bibliographic Information
Book Title: Fc Mediated Activity of Antibodies
Book Subtitle: Structural and Functional Diversity
Editors: Jeffrey V. Ravetch, Falk Nimmerjahn
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-030-31053-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-31052-3Published: 19 September 2019
Softcover ISBN: 978-3-030-31055-4Published: 19 September 2020
eBook ISBN: 978-3-030-31053-0Published: 03 September 2019
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 150
Number of Illustrations: 2 b/w illustrations, 12 illustrations in colour
Topics: Immunology, Cancer Research, Infectious Diseases