Natural Products as Source of Molecules with Therapeutic Potential

1. Front Matter

   Pages i-xii

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2. Medicinal Plants and Phytomedicines

   • Rivaldo Niero, Valdir Cechinel Filho, Rosendo Augusto Yunes

   Pages 1-33

3. Plant Products with Antifungal Activity: From Field to Biotechnology Strategies

   • Giovanna Simonetti, Alessio Valletta, Olga Kolesova, Gabriella Pasqua

   Pages 35-71

4. Liquid Chromatography for Plant Metabolite Profiling in the Field of Drug Discovery

   • Luiz Carlos Klein-Júnior, Johan Viaene, Amorn Slosse, Yvan Vander Heyden

   Pages 73-109

5. Functional Foods as Source of Bioactive Principles: Some Marked Examples

   • Adriana Campos, Elisa Brasili, Camile Cecconi Cechinel-Zanchett, Valdir Cechinel Filho

   Pages 111-157

6. The Role of Flavonoids as Modulators of Inflammation and on Cell Signaling Pathways

   • Liliana V. Muschietti, Jerónimo L. Ulloa, Flavia DC. Redko

   Pages 159-208

7. Current Approaches to the Isolation and Structural Elucidation of Active Compounds from Natural Products

   • Alice L. Perez

   Pages 209-231

8. Syntheses of Asymmetrically Substituted Pyrans of Natural Origin

   • Wiesław Szeja, Grzegorz Grynkiewicz

   Pages 233-307

9. Natural Products as Sources of Anticancer Agents: Current Approaches and Perspectives

   • Gordon M. Cragg, David J. Newman

   Pages 309-331

10. Virtual Screening for the Discovery of Active Principles from Natural Products

    • Benjamin Kirchweger, Judith M. Rollinger

    Pages 333-364

11. Current Regulatory Environment of Herbal Medicinal Products in the European Union

    • Werner Knöss

    Pages 365-389

12. Development and Use of Polymeric Nanoparticles for the Encapsulation and Administration of Plant Extracts

    • Ashik Mosaddik, Vijaya Ravinayagam, Silviya Elaanthikkal, Hatem Fessi, Waisudin Badri, Abdelhamid Elaissari

    Pages 391-463

13. NMR Identification of Biologically Active Natural Products: Strategies and Challenges

    • Gloria Ivonne Hernández-Bolio, Luis Manuel Peña-Rodríguez

    Pages 465-494

14. Herbal Medicine and Public Healthcare: Current and Future Challenges

    • Dâmaris Silveira, Jose M. Prieto, Marcela M. Freitas, Andre L. D. A. Mazzari

    Pages 495-515

15. Back Matter

    Pages 517-531

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This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs.

Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios.

Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

• Medicinal plants
• Active principles
• Drug research
• Chromatographic techniques
• Espectrometric techniques
• Functional foods
• Stereoselective synthesis
• Biological assays
• Anticancer agents
• Phytotherapics

• University of Vale do Itajaí – UNIVALI, Itajaí, Brazil

  Valdir Cechinel Filho

Valdir Cechinel Filho is a Professor/researcher at the Postgraduate Program (M/D) in Pharmaceutical Sciences of the University of Vale do Itajaí (UNIVALI) in Santa Catarina, Brazil. He has experienced in the field of Organic Chemistry, focusing on the following topics: bioactive natural products, synthesis of molecules of biological interest, and investigation of the relationship between chemical structure and biological activity. Editor of six books, over twenty contributed chapters and over 300 papers and reviews, besides 12 patents. In 2017, he received the highest Commendation of Academic Merit of the Council of Rectors of Brazilian Universities (CRUB) for his contribution to the Brazilian Higher Education. In March 2018, he became President of the Foundation UNIVALI and Rector of UNIVALI, with a mandate to head the institution until 2022.

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