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Viral Vector Approaches in Neurobiology and Brain Diseases

  • Book
  • © 2014

Overview

Editors:
  1. Riccardo Brambilla

    1. Institute of Experimental Neurology, San Raffaele Scientific Institute Division of Neuroscience, Milan, Italy

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  • Covers relevant aspects with a major emphasis on basic mechanisms of synaptic plasticity, learning/memory, molecular neuropharmacology, and experimental animal models
  • Focuses on use of practical genetic approaches in current neuroscience research
  • Features proven applications and techniques
  • Includes supplementary material: sn.pub/extras

Part of the book series: Neuromethods (NM, volume 82)

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Table of contents (17 protocols)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Types of Viral Vectors in Neuroscience Research

    1. Front Matter

      Pages 1-1
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    2. Lentiviral Vectors as Research Tools in Neurobiology: Design and Production

      • Alessandro Papale, Riccardo Brambilla
      Pages 3-10

    3. Recombinant Adenovirus in Neurobiology

      • Qian Li, Tong-Chuan He
      Pages 11-25

    4. Adeno-Associated Virus-Based Vectors

      • Nathalie Dutheil, Erwan Bezard
      Pages 27-49

    5. Herpes Simplex Virus 1 (HSV-1)-Based Vectors

      • Aldo Pourchet, Matias E. Melendez, Anna Greco, Alberto L. Epstein
      Pages 51-93

    6. Alphavirus-Based Vectors

      • Kenneth Lundstrom
      Pages 95-111

  3. Viral Vectors in Memory Research and Psychiatric Diseases

    1. Front Matter

      Pages 113-113
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    2. Viral Vectors to Study Synaptic Function

      • Hélène Marie
      Pages 115-136

    3. Using Viral Vectors to Study the Memory Trace in Mice

      • Asim J. Rashid, Chen Yan, Sheena A. Josselyn
      Pages 137-154

    4. Development of Cell-Type-Specific Viral Vectors to Tease Apart the Neural Circuitry that Contributes to Drug Addiction

      • Susan M. Ferguson, John F. Neumaier
      Pages 155-164

    5. Using Viral-Mediated Gene Transfer to Study Depressive-Like Behavior

      • Amy R. Furay, John F. Neumaier
      Pages 165-177

  4. Viral Vectors in Neurological Disorders

    1. Front Matter

      Pages 179-179
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    2. Gene Therapy for Parkinson’s Disease

      • Erika Elgstrand Wettergren, Luis Quintino, Giuseppe Manfré, Cecilia Lundberg
      Pages 181-191

    3. Lentiviral Vectors in Huntington’s Disease Research and Therapy

      • Aurélie Delzor, Noëlle Dufour, Nicole Déglon
      Pages 193-220

    4. Application of Viral Vectors to Motor Neuron Disorders

      • Elisabeth Dirren, Bernard L. Schneider
      Pages 221-242

  5. Applications of Viral Vector Technology to Neuroscience Research

    1. Front Matter

      Pages 243-243
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    2. In Vivo Gene Silencing by Virally Delivered MicroRNA

      • Eugenia V. Gurevich, Mohamed R. Ahmed, Yonatan Carl
      Pages 245-267

    3. Viral Manipulation of Neural Stem/Precursor Cells

      • Nunzio Iraci, Giulia Elisabetta Tyzack, Chiara Cossetti, Clara Alfaro-Cervello, Stefano Pluchino
      Pages 269-288

    4. Viral Vector-Based Techniques for Optogenetic Modulation In Vivo

      • Mathias Mahn, Shiri Ron, Ofer Yizhar
      Pages 289-310
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Keywords

About this book

Aiming toward improvement in the safety, efficiency, and specificity of viral vectors for neurobiological research and clinical applications, Viral Vector Approaches in Neurobiology and Brain Diseases covers key aspects related to the use of viral vectors in neuroscience, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain disorders.  The volume begins by delving into features of the viral vectors currently available in neuroscience and their production methods, and it then continues onward to examples of successful applications of viral vector technology to psychiatric and memory research, current applications of viral vector technology in the context of neurological disorders, as well as various cutting-edge applications of viral vector technology to neuroscience, including optogenetics.  Written for the Neuromethods series, the chapters of this book contain the kind of detailed description and implementation advice that promotes successful, repeatable results.

 

Practical and up to date, Viral Vector Approaches in Neurobiology and Brain Diseases will be useful not only to neurobiologists wishing to routinely use viral vectors in the laboratory but also to experienced scientists needing detailed new protocols for a variety of experimental applications.

Editors and Affiliations

  • Institute of Experimental Neurology, San Raffaele Scientific Institute Division of Neuroscience, Milan, Italy

    Riccardo Brambilla

Bibliographic Information

  • Book Title: Viral Vector Approaches in Neurobiology and Brain Diseases

  • Editors: Riccardo Brambilla

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-62703-610-8

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC 2014

  • Hardcover ISBN: 978-1-62703-609-2Published: 16 October 2013

  • Softcover ISBN: 978-1-4939-5943-3Published: 23 August 2016

  • eBook ISBN: 978-1-62703-610-8Published: 16 October 2013

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XIII, 347

  • Number of Illustrations: 17 b/w illustrations, 34 illustrations in colour

  • Topics: Neurosciences, Human Genetics

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