Transgenic and Knockout Models of Neuropsychiatric Disorders

1. Front Matter

   Pages i-xii

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2. Introduction and Overview

   1. Front Matter

      Pages 1-1

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   2. Transgenic and Knockout Models of Psychiatric Disorders

      • Gene S. Fisch

      Pages 3-23

   3. Transgenic Mouse Models and Human Psychiatric Disease

      • Jonathan Flint

      Pages 25-43

   4. Transgenic and Knockout Mouse Models

      • Linda J. Hayes, Diana Delgado

      Pages 45-67

   5. If Only They Could Talk

      • Trevor Humby, Lawrence Wilkinson

      Pages 69-83

3. Transgenic and Knockout Models of Neurocognitive Dysfunction

   1. Front Matter

      Pages 85-85

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   2. Spinocerebellar Ataxia Type 1

      • Harry T. Orr

      Pages 87-99

   3. Mouse Models of Hereditary Mental Retardation

      • Hans Welzl, Patrizia D’Adamo, David P. Wolfer, Hans-Peter Lipp

      Pages 101-125

   4. How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders?

      • Simon E. Fisher

      Pages 127-149

   5. Animal Models of Autism

      • Thomas Bourgeron, Stéphane Jamain, Sylvie Granon

      Pages 151-174

4. Transgenic and Knockout Models of Neuropsychiatric Dysfunction

   1. Front Matter

      Pages 175-175

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   2. Genetic Mouse Models of Psychiatric Disorders

      • Joseph A. Gogos, Maria Karayiorgou

      Pages 177-191

   3. Animal Models of Psychosis

      • Stephen I. Deutsch, Katrice Long, Richard B. Rosse, Yousef Tizabi, Ronit Weizman, Judy Eller et al.

      Pages 193-220

   4. Animal Models of Anxiety

      • Robert Gerlai, Robert Blanchard, Caroline Blanchard

      Pages 221-236

   5. Modeling Human Anxiety and Depression in Mutant Mice

      • Andrew Holmes, John F. Cryan

      Pages 237-263

   6. Mutant Mouse Models of Bipolar Disorder

      • Anneloes Dirks, Lucianne Groenink, Berend Olivier

      Pages 265-285

5. Back Matter

   Pages 287-296

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In this up-to-date survey and critical assessment of transgenic and knockout models in neuropsychiatry and behavior, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, and speech disorders, as well as disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder.

• depression
• psychiatry
• schizophrenia

• Department of Statistics, Yeshiva University, New York

  Gene S. Fisch

• Department of Psychology, CUNY/Lehman College, New York

  Gene S. Fisch

• Wellcome Trust Centre for Human Genetics, Oxford, UK

  Jonathan Flint

• Department of Psychiatry, University of Oxford, Oxford, UK

  Jonathan Flint

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