Handbook of Drug'Nutrient Interactions

1. Front Matter

   Pages i-xvii

   PDF

2. Overview of Drug-Nutrient Interactions

   1. Front Matter

      Pages 1-1

      PDF

   2. A Perspective on Drug-Nutrient Interactions

      • Joseph I. Boullata, Jacqueline R. Barber

      Pages 3-25

   3. Drug Disposition and Response

      • Robert B. Raffa

      Pages 27-42

   4. Drug-Metabolizing Enzymes and P-Glycoprotein

      • Thomas K. H. Chang

      Pages 43-67

   5. Nutrient Disposition and Response

      • Francis E. Rosato Jr.

      Pages 69-80

3. Influence of Nutritional Status on Drug Disposition and Effect

   1. Front Matter

      Pages 81-81

      PDF

   2. The Impact of Protein-Calorie Malnutrition on Drugs

      • Charlene W. Compher

      Pages 83-99

   3. Influence of Obesity on Drug Disposition and Effect

      • Joseph I. Boullata

      Pages 101-126

4. Influence of Food or Nutrients on Drug Disposition and Effect

   1. Front Matter

      Pages 127-127

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   2. Drug Absorption With Food

      • David Fleisher, Burgunda V. Sweet, Ameeta Parekh

      Pages 129-154

   3. Effects of Specific Foods and Non-Nutritive Dietary Components on Drug Metabolism

      • Karl E. Anderson

      Pages 155-173

   4. Grapefruit Juice-Drug Interaction Issues

      • David G. Bailey

      Pages 175-194

   5. Nutrients That May Optimize Drug Effects

      • Imad F. Btaiche, Michael D. Kraft

      Pages 195-216

   6. Dietary Supplement Interactions With Medication

      • Jeffrey J. Mucksavage, Lingtak-Neander Chan

      Pages 217-233

   7. Dietary Supplement Interaction With Nutrients

      • Mariana Markell

      Pages 235-240

5. Influence of Pharmaceuticals on Nutritional Status, Nutrient Disposition, and Effect

   1. Front Matter

      Pages 241-241

      PDF

   2. Drug-Induced Changes to Nutritional Status

      • Jane M. Gervasio

      Pages 243-256

   3. Cardiac Drugs and Nutritional Status

      • Honesto M. Poblete Jr., Raymond C. Talucci II

      Pages 257-270

   4. Drug-Nutrient Interactions Involving Folate

      • Leslie Schechter, Patricia Worthington

      Pages 271-284

Although there is agreat deal ofliterature regarding drug-nutrientinteractions (DNis ), there are limited sources of up-to-date comprehensive information. The Handbook of Drug-Nutrient Interactions admirably fills this gap. The editors, Dr. Joseph 1. Boullata and Dr. Vincent T. Armenti, ha ve a wealth of experience in this therapeutic ar ea and ha ve assembled a fine cadre of chapter authors who have individually contributed their high level of expertise. As treatment for many diseases becomes increasingly complex with multiple drug therapies scheduled at varying times, the need to identify clinically significant DNis is an essential part of medication management. This is a shared responsibility between health care professionals to interpret available data and individualize an approach to therapy that is compatible with the patient' s disease state, life stage, and dietary intake. Awareness ofthe significance of drug-food interactions is generally lacking. Although many texts contain lengthy lists of possible interactions, few data are provided for the clinician to gain an understanding of the mechanism of action of the interaction and subsequently apply the information to a particular patient or group of patients. For example, in the management of patients with HN -AIDS who are taking complex prescribed drug regimens, herbal products, and nutritional supplements, many of which are affected by dietary intake, careful attention to D Nls is a critic al component of therapy. Clinicians need to take account of not only the well-documented interactions between drugs and nutrients, but also the less obvious effects on drug-nutrient disposition and metabolism.

• Absorption
• Calcium
• Malnutrition
• Nutrition
• cancer
• enzymes
• metabolism

From the reviews:

"This is a useful guide to understanding the science behind nutrient-drug interactions. It offers in-depth understanding of the critical role that such interactions may have on the patient's outcome. . .this book helps the reader to better understand, identify, prevent, or manage potential adverse effects of drug-nutrient interactions. 5 Stars!"-Doody's Health Sciences and Book Review Journal

"Comprehensive resource for pharmacists, physicians, dietitians, and nurses. Libraries supporting the health sciences should include it in their reference collections for students and faculty." - American Reference Books Annual 2005

"At all stages of the life cycle, prescription drugs have become an increasing part of our lives. … This book provides a valuable resource but makes it clear that this is a new science with a long way to go. … it is well written and clearly laid out. Each chapter contains numerous charts and graphs as well as a reference list. It would be a valuable addition to a professional library and could serve as a text for an advanced graduate class." (Elaine Kris Ludman, Journal of Nutrition for the Elderly, September, 2005)

• Department of Pharmacy Practice, Temple University School of Pharmacy, Philadelphia, USA

  Joseph I. Boullata

• Department of Surgery, Temple University School of Medicine, Philadelphia, USA

  Vincent T. Armenti

Policies and ethics