Cytokines and Autoimmune Diseases

1. Front Matter

   Pages i-xi

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2. Cytokines: Induction and Regulation

   1. Front Matter

      Pages 1-1

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   2. Transcriptional Regulation of Cytokine Gene Expression in Th Subsets

      • Jyothi Rengarajan, Laurie H. Glimcher

      Pages 3-23

   3. Chromatin Remodeling and Transcriptional Regulation of Cytokine Gene Expression in T Cells

      • M. Frances Shannon, Adele F. Holloway

      Pages 25-48

   4. Variant Ligands, Altered T Cell Receptor Signaling, Hierarchical Response Thresholds, and CD4+ Effector Responses

      • Yasushi Itoh, Ronald N. Germain

      Pages 49-78

   5. The Role of Costimulation in T Cell Differentiation

      • Janet E. Buhlmann, Arlene H. Sharpe

      Pages 79-118

   6. CD1d-Restricted NK T Cells and Autoimmunity

      • Mark Exley, S. Brian Wilson

      Pages 119-141

   7. Role of T Cell Death and Cytokines in Autoimmunity

      • Luk Van Parijs, Abul K. Abbas

      Pages 143-156

   8. Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease

      • Richard M. Ransohoff, William J. Karpus

      Pages 157-191

3. Cytokines: Role in Specific Autoimmune Diseases

   1. Front Matter

      Pages 193-193

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   2. Cytokines and Resistance to Organ Specific Autoimmune Disease

      • Benjamin M. Segal, Ethan M. Shevach

      Pages 195-225

   3. The Role of Cytokines in Induction and Regulation of Autoimmune Uveitis

      • Rachel R. Caspi

      Pages 227-245

   4. Pathogenic and Regulatory Cytokines in Experimental Autoimmune Encephalomyelitis

      • Estelle Bettelli, Lindsay B. Nicholson

      Pages 247-271

   5. Role of Cytokines in Multiple Sclerosis and in Mucosal Tolerance

      • Howard L. Weiner

      Pages 273-293

   6. Cytokines and Human Type 1 Diabetes

      • Sally C. Kent, Vissia Viglietta, David A. Hafler

      Pages 295-316

   7. Cytokines in Human Rheumatoid Arthritis and Murine Models

      • Marie Wahren-Herlenius, Helena Erlandsson Harris, Per Larsson, Lars Klareskog

      Pages 317-354

   8. Systemic Lupus Erythematosus

      • Amy E. Wandstrat, Edward K. Wakeland

      Pages 355-371

   9. Myasthenia Gravis

      • Premkumar Christadoss, Elzbieta Goluszko

      Pages 373-385

4. Cytokines and Autoimmunity: A Synthesis

   1. Front Matter

      Pages 387-387

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   2. Cytokines in Autoimmune Disease

      • Vijay K. Kuchroo, Lindsay B. Nicholson

      Pages 389-406

Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

• Chemokine
• T cell
• autoimmune disease
• autoimmunity
• cytokine
• diseases
• pathogenesis
• resistance

"Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease." -Immunology News

• Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA

  Vijay K. Kuchroo, David A. Hafler, Lindsay B. Nicholson

• Department of Immunology, Scripps Research Institute, La Jolla, USA

  Nora Sarvetnick

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