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Cyclic Peptide Design

  • Book
  • © 2019

Overview

Editors:
  1. Gilles Goetz

    1. Hit Discovery and Optimization, Pfizer R&D, Groton, USA

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  • Includes cutting-edge techniques
  • Provides detail essential for successful results
  • Contains key advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2001)

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Table of contents (15 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Design Principles for Intestinal Permeability of Cyclic Peptides

    • Alan M. Mathiowetz
    Pages 1-15

  3. Strategies to Enhance Metabolic Stabilities

    • Bhavesh Khatri, Venkateswara Rao Nuthakki, Jayanta Chatterjee
    Pages 17-40

  4. Designing Cell-Permeable Macrocyclic Peptides

    • George Appiah Kubi, Patrick G. Dougherty, Dehua Pei
    Pages 41-59

  5. Computational Methods for Studying Conformational Behaviors of Cyclic Peptides

    • Fan Jiang, Hao Geng
    Pages 61-71

  6. Computational Opportunities and Challenges in Finding Cyclic Peptide Modulators of Protein–Protein Interactions

    • Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, Denis Shields
    Pages 73-95

  7. Design of Cyclic Peptides as Protein Recognition Motifs

    • Ye Che
    Pages 97-106

  8. Design and Synthetic Strategies for Helical Peptides

    • Licheng Tu, Dongyuan Wang, Zigang Li
    Pages 107-131

  9. Click Chemistry for Cyclic Peptide Drug Design

    • Adel Ahmed Rashad
    Pages 133-145

  10. Frontier Between Cyclic Peptides and Macrocycles

    • Philipp Ermert, Anatol Luther, Peter Zbinden, Daniel Obrecht
    Pages 147-202

  11. Building upon Nature’s Framework: Overview of Key Strategies Toward Increasing Drug-Like Properties of Natural Product Cyclopeptides and Macrocycles

    • Maria-Jesus Blanco
    Pages 203-233

  12. Design of Oxytocin Analogs

    • Kazimierz Wiśniewski
    Pages 235-271

  13. DNA-Encoded Macrocyclic Peptide Library

    • Zhengrong Zhu, Alex Shaginian, La Shadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal et al.
    Pages 273-284

  14. Peptide Display Technologies

    • Anthony Pitt, Zeke Nims
    Pages 285-298

  15. Discovery of Functional Macrocyclic Peptides by Means of the RaPID System

    • Christos Tsiamantas, Manuel E. Otero-Ramirez, Hiroaki Suga
    Pages 299-315

  16. Genetic Selections with SICLOPPS Libraries: Toward the Identification of Novel Protein–Protein Interaction Inhibitors and Chemical Tools

    • Francisco Castillo, Ali Tavassoli
    Pages 317-328

  17. Back Matter

    Pages 329-332
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Keywords

About this book

This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. 

Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.

Editors and Affiliations

  • Hit Discovery and Optimization, Pfizer R&D, Groton, USA

    Gilles Goetz

Bibliographic Information

  • Book Title: Cyclic Peptide Design

  • Editors: Gilles Goetz

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-9504-2

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2019

  • Hardcover ISBN: 978-1-4939-9503-5Published: 28 May 2019

  • Softcover ISBN: 978-1-4939-9506-6Published: 14 August 2020

  • eBook ISBN: 978-1-4939-9504-2Published: 27 May 2019

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 332

  • Number of Illustrations: 58 b/w illustrations, 80 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Biochemistry, general, Cell Physiology

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