G Protein-Coupled Receptor Kinases

1. Front Matter

   Pages i-xi

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery

      • Vsevolod V. Gurevich, Eugenia V. Gurevich

      Pages 3-22

3. GRK Structure, Mechanisms of Activation, and Interactions with GPCRs

   1. Front Matter

      Pages 23-23

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   2. Structure and Function of G-Protein-Coupled Receptor Kinases 1 and 7

      • Tivadar Orban, Krzysztof Palczewski

      Pages 25-43

   3. Visual G Protein-Coupled Receptor Kinases

      • Chih-Chun Hsu, Ching-Kang Jason Chen

      Pages 45-57

   4. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily

      • Tyler S. Beyett, Sumit J. Bandekar, John J. G. Tesmer

      Pages 59-74

   5. “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs

      • Kunhong Xiao, Hongda Liu

      Pages 75-120

4. GRKs in Cell Signaling

   1. Front Matter

      Pages 121-121

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   2. Cell-Type Specific GRK2 Interactomes: Pathophysiological Implications

      • Federico Mayor Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas et al.

      Pages 123-149

   3. Differential Regulation of IGF-1 and Insulin Signaling by GRKs

      • Leonard Girnita, Ada Girnita, Caitrin Crudden

      Pages 151-171

   4. Differential Control of Potassium Channel Activity by GRK2

      • Adi Raveh, Liora Guy-David, Eitan Reuveny

      Pages 173-183

5. Physiological and Pathophysiological Mechanisms Regulated by GRKs

   1. Front Matter

      Pages 185-185

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   2. Critical Role of GRK2 in the Prevention of Chronic Pain

      • Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, Annemieke Kavelaars

      Pages 187-213

   3. Roles of GRK Dysfunction in Alzheimer’s Pathogenesis

      • William Z. Suo

      Pages 215-236

   4. Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases

      • Eugenia V. Gurevich, Raul R. Gainetdinov, Vsevolod V. Gurevich

      Pages 237-269

   5. G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation

      • Alessandro Cannavo, Claudio de Lucia, Walter J. Koch

      Pages 271-281

   6. GRK Roles in C. elegans

      • Jordan F. Wood, Denise M. Ferkey

      Pages 283-299

   7. Evolutionarily Conserved Role of G-Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway

      • Dominic Maier, David R. Hipfner

      Pages 301-324

6. Back Matter

   Pages 325-329

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This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

• G protein-coupled receptors (GPCRs)
• Cell signaling
• Pathophysiological regulation
• GPCR signaling
• GRK phosphorylation
• Therapeutic strategies
• GRKs

• Department of Pharmacology, Vanderbilt University , NASHVILLE, USA

  Vsevolod V. Gurevich

• Department of Pharmacology, Vanderbilt University, Nashville, USA

  Eugenia V. Gurevich

• Life Sciences Institute, University of Michigan, Ann Arbor, USA

  John J.G. Tesmer

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