Overview
- Authors:
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Jose Russo
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Fox Chase Cancer Center, Philadelphia, USA
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Irma H. Russo
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Fox Chase Cancer Center, Philadelphia, USA
Explores various cutting-edge methodologies used in breast cancer research, including stem cell separation, molecular analysis of gene function and more
Explores imaging techniques that are integral for studying the physiopathology of breast cancer
Authors are well known in the field of breast cancer
Includes supplementary material: sn.pub/extras
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Table of contents (10 chapters)
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- Jose Russo, Irma H. Russo
Pages 1-44
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- Jose Russo, Irma H. Russo
Pages 45-73
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- Jose Russo, Fathima Sheriff, Ricardo Lopez de Cicco, Thomas J. Pogash, Theresa Nguyen, Irma H. Russo
Pages 75-102
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- Jose Russo, Fathima Sheriff, Thomas J. Pogash, Theresa Nguyen, Julia Santucci-Pereira, Irma H. Russo
Pages 103-118
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- Jose Russo, Thomas J. Pogash, Janine Gomes, Justin Newton, Ricardo Lopez de Cicco, Yanrong Su et al.
Pages 119-150
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- Yanrong Su, Pedro J. Gutiérrez Diez, Julia Santucci-Pereira, Irma H. Russo, Jose Russo
Pages 151-182
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- Jose Russo, Ricardo Lopez de Cicco, Yanrong Su, Thomas J. Pogash, Nathan Hopfinger, Irma H. Russo
Pages 183-216
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- Jose Russo, Ricardo Lopez de Cicco, Thomas J. Pogash, Irma H. Russo
Pages 217-233
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- Julia Santucci-Pereira, Maria Barton, Irma H. Russo, Jose Russo
Pages 235-252
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- Julia Santucci-Pereira, Steven G. Doll, Ryan R. Smalley, Colleen O’Malley, Irma H. Russo, Jose Russo
Pages 253-283
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Back Matter
Pages 285-287
About this book
This volume explores the myriad of techniques and methodological approaches that are being used in breast cancer research. The authors critically evaluate of the advantages and disadvantages of current methodologies, starting with the tools available for understanding the architecture of the human breast, including its tissue and cellular composition. The volume discusses the importance of functional studies in breast cancer research, especially with the help of laser capture microdissection, which allows the separation of small amounts of tissue, as well as specific cells, for biochemical analysis. In addition, the authors address methodologies including stem cell separation, which has helped in significantly understanding their role in normal breast development, but also further the understanding of breast cancer and its therapeutic management. The use of in vitro techniques and established cell lines for mechanistic studies in chemotherapeutic approaches have been invaluable will be discussed. Imaging techniques for evaluating in vitro and in vivo behavior of normal and cancerous breast tissue will be explored, as it provides a better understanding of the physiopathology of cancer. The volume will also discuss the molecular analysis of gene function in breast cancer through the transcriptomic and epigenomic profile. More importantly, the advancement of more refined techniques in sequencing will be covered. This monograph will be a comprehensive, authoritative and timely, as it addresses the emerging approaches used in breast cancer research.
About the authors
Jose Russo, M.D., FACP is a Professor and Senior Member for the Fox Chase Cancer Center. He is also the Director of the Breast Cancer and Environment Research Center at Fox Chase .In addition to his roles at Fox Chase, he is simultaneously an Adjunct Professor of Pathology and Cell Biology at Jefferson Medical College, as well as an Adjunct Professor of Biochemistry at Temple Medical School. His primary research interest includes breast cancer, endocrinology, hormonal and environmental carcinogenesis. He's received several academic and research awards for his outstanding work in the field. He's a member of numerous scientific and professional societies. He has published over 350 scientific papers. He also serves on several editorial boards for several journals including, International Journal of Oncology, Hormone Molecular Biology and Clinical Investigation, and the Journal of Medical Hypothesis and Research. In addition, he's the editor-in-chief of the Journal of Women's Cancer. He's also published several books with Springer in the past. Irma Russo, M.D., FACP, FASCP is Associate Professor at the Fox Chase Cancer Center and the Chief of the Molecular Endocrinology Section oat the Breast Cancer Research Lab. She has over 190 scientific publications.
