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Reproductive Toxicology

In Vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand

  • Book
  • © 1998

Overview

Editors:
  1. Jesús Mazo

    1. Centro de Investigaciones Biológicas (CISC), Madrid, Spain

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 444)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Advances in Improving Human Risk Estimation

    1. Trends in Male Reproductive Health. Environmental Aspects

      • Niels E. Skakkebaek
      Pages 1-4

    2. Organochlorine Compounds and Xenoestrogens in Human Endometrium

      • Wolfgang R. Schäfer, Hans Peter Zahradnik
      Pages 5-8

    3. Assays to Measure Estrogen and Androgen Agonists and Antagonists

      • Ana M. Soto, Cheryl L. Michaelson, Nancy V. Prechtl, Beau C. Weill, Carlos Sonnenschein, Fatima Olea-Serrano et al.
      Pages 9-28

    4. Development of a Marker of Estrogenic Exposure in Breast Cancer Patients

      • Patricia Pazos, Pilar Pérez, Ana Rivas, Rafael Nieto, Begoña Botella, Jorge Crespo et al.
      Pages 29-40

  3. New Approaches for In Vitro Analysis of Germ Cells Exposure to Toxicological Agents

    1. In Vitro Culture Systems for Germ Cells from Mouse Embryo: Primordial Germ Cells and Oocytes

      • Massimo De Felici
      Pages 41-49

    2. Cell Culture Systems for the Analysis of the Male Germinal Differentiation

      • Minoo Rassoulzadegan, François Cuzin
      Pages 51-57

    3. In Vitro Survival of Human Neoplastic Germ Cells

      • Ewa Rajpert-De Meyts, Heidrun Lauke, Niels E. Skakkebæk
      Pages 59-66

    4. Effects of Rapamycin and FK 506 on Rat Sertoli Cells In Vitro

      • Nicole Clemann, Rudolf Bechter
      Pages 67-71

    5. Flow Cytometry as a Tool for the Evaluation of Testicular Toxicity

      • Maria Bobadilla, Laura Suter, Rudolf Bechter
      Pages 73-78

    6. DNA Damage in Human and Mouse Spermatozoa after In Vitro-Irradiation Assessed by the Comet Assay

      • Grant Haines, Brian Marples, Paul Daniel, Ian Morris
      Pages 79-93

    7. In Vitro Models for the Investigation of Reproductive Toxicology in the Testis

      • Brian A. Cooke
      Pages 95-103

    8. Effect of Metal Compounds on Boar Sperm Motility In Vitro

      • Mario Altamirano-Lozano, Elia Roldán, Edmundo Bonilla, Miguel Betancourt
      Pages 105-111

    9. In Vitro Analysis of Xenoestrogens by Enzyme Linked Receptor Assays (ELRA)

      • Martin Seifert, Stefanie Haindl, Bertold Hock
      Pages 113-117

  4. Molecular and Developmental Approaches for Assessing Reproductive Toxicity:

    1. Current and Future Contributions of Transgenic Mice to the Analysis of Germline Toxicology

      • A. Collick, Philippe Bois, Gemma Grant, Jerome Buard
      Pages 119-127

    2. Evaluation of the Placenta: Suggestions for a Greater Role in Developmental Toxicology

      • F. Maranghi, C. Macrì, C. Ricciardi, A. V. Stazi, A. Mantovani
      Pages 129-136

    3. Protective Mechanisms in Germ Cells: Stress Proteins in Spermatogenesis

      • David J. Dix, Robert L. Hong
      Pages 137-144

    4. Molecular Cloning and Developmental Pattern of Expression of MSJ-1, a New Male Germ Cell-Specific DnaJ Homologue

      • Giovanna Berruti, Lucia Perego, Enzo Martegani
      Pages 145-151

    5. Analysis of Gene Regulation in Sertoli Cells by a Gene Trap Approach

      • Luis A. López-Fernández, Pascal Lopez, Fréderique Vidal, Fariba Ranc, François Cuzin, Minoo Rassoulzadegan
      Pages 153-162

    6. Biochemical Characterization of Benomyl Inhibition on Endometrial Growth During Decidualization in Rats

      • Fitzgerald Spencer, Limen Chi, Ming-Xia Zhu
      Pages 163-169
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Keywords

About this book

Numerous reports demonstrate that the reproductive system could be affected by multiple potential toxicological agents. The volume includes different aspects of the development of new approaches to in vitro testing using sperm cells and systems involved on reproduction in mammals. Comparative analysis of in vivo and in vitro methods has been included to take steps towards the further development of and applications of new systems for germline toxicology.

Editors and Affiliations

  • Centro de Investigaciones Biológicas (CISC), Madrid, Spain

    Jesús Mazo

Bibliographic Information

  • Book Title: Reproductive Toxicology

  • Book Subtitle: In Vitro Germ Cell Developmental Toxicology, from Science to Social and Industrial Demand

  • Editors: Jesús Mazo

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4899-0089-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1998

  • Hardcover ISBN: 978-0-306-46025-8Published: 31 October 1998

  • Softcover ISBN: 978-1-4899-0091-3Published: 31 May 2013

  • eBook ISBN: 978-1-4899-0089-0Published: 29 June 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 223

  • Topics: Pharmacology/Toxicology, Public Health, Environmental Management, Gynecology

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