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Mass Spectrometry in Biotechnological Process Analysis and Control

  • Book
  • © 1987

Overview

Editors:
  1. Elmar Heinzle

    1. Chemical Engineering Laboratory, ETH, Zurich, Switzerland

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  2. Matthias Reuss

    1. Technical University of Berlin, Berlin, Federal Republic of Germany

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xi
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  2. Introduction

    1. Introduction

      • Elmar Heinzle, Matthias Reuss
      Pages 1-6

  4. Membrane Inlet Systems

    1. Membrane Inlets for on-Line Liquid-Phase Mass Spectrometric Measurements in Bioreactors

      • Raimond Peter Cox
      Pages 63-74

    2. Optimisation of a MS-Membrane Probe for the Measurement of Acetoin and Butanediol

      • M. Griot, E. Heinzle, I. J. Dunn, J. R. Bourne
      Pages 75-90

    3. Methanogenesis in the Rumen: Mass Spectrometric Monitoring

      • D. Lloyd, A. G. Williams, K. Hillman, T. N. Whitmore
      Pages 91-103

    4. Gas Analysis and Membrane Probes

      • M. Reuss
      Pages 105-114

  5. Applications and Computer Control

    1. Application of MS to Industrial Fermentation

      • S. Bohatka, J. Szilagyi, G. Langer
      Pages 115-123

    2. Characterization of Bioreactors by Mass Spectrometry Analysis

      • A. Luebbert, S. Froehlich, K. Schuegerl
      Pages 125-142

    3. Methanogenesis in Mesophilic and Thermophilic Anaerobic Digesters: Monitoring and Control Based on Dissolved Hydrogen

      • T. N. Whitmore, G. Jones, M. Lazzari, D. Lloyd
      Pages 143-162

    4. On-Line Mass Spectrometry in the Analysis of Eight Gases During the Microbial Oxidation of Gaseous Hydrocarbons

      • Anthony O’L. Richards, Stephen H. Stanley, Howard Dalton
      Pages 163-177

    5. The Use of Mass Spectrometry in the Screening of Microorganisms on Productivity

      • Marcel W. W. M. van Tilborg
      Pages 179-186

  6. Pyrolysis-MS and HPLC-MS Interfacing

    1. Differentiation of Phage Sensitive and Phage Resistant Streptococcus Cremoris Strains by Pyrolysis Mass Spectrometry and Discriminant Analysis of the Cell Walls

      • Jaap J. Boon, B. Brandt-de Boer, G. B. Eijkel, Elly Vlegels, Lolke Sijtsma, Jan T. M. Wouters
      Pages 187-208

    2. Development of an On-Line Pyrolysis Mass Spectrometry System for the On-Line Analysis of Fermentations

      • E. P. Sandmeier, J. Keller, E. Heinzle, I. J. Dunn, J. R. Bourne
      Pages 209-215

    3. Developments in HPLC-MS Interfacing

      • E. P. Lankmayr
      Pages 217-223

    4. Mass Spectrometry for Control of Fermentation

      • C. L. Cooney
      Pages 225-230

  7. Back Matter

    Pages 231-241
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Keywords

About this book

This book is based on the contributions to the IFAC-Workshop "Mass Spectro­ metry in Biotechnological Process Analysis and Control" held in Graz, Austria from 23 to 24 October 1986. The idea to organize this workshop and further to prepare these proceedings was stimulated by the following facts. Biotechnological processes urgently need better on-line instrumentation. Mass spectrometry (MS) offers a great potential to especially analyse gases and volatile compounds. It is, however, considered that this potential by far is not exhausted. The main reason for this is that MS often still is considered to be a very expensive technique requiring the permanent attention of a MS expert. In addition methods have not yet been developed to a user friendly state. On-line MS-methods are available to a certain extent, but need further development. To stimulate such development an interdisciplinary effort is necessary. Needs of industrial and university users and experience of physicists and instrument manufacturers have to be brought into a hopefully fruitful discussion. An introductory article describes the bioprocess background including a brief summary of the state of the art in bioprocess sensor and parameter estimation development, and the potential MS offers for bioprocess monitoring. In the first chapter on "Instrumentation and Gas Analysis" a general overview on some developments in MS-instrumentation is given initially by Schmid. Then the presently available instrumentation for bioprocess monitoring is discussed by instrument manufacturers (Winter; Schaefer and Schultis; Bartman).

Editors and Affiliations

  • Chemical Engineering Laboratory, ETH, Zurich, Switzerland

    Elmar Heinzle

  • Technical University of Berlin, Berlin, Federal Republic of Germany

    Matthias Reuss

Bibliographic Information

  • Book Title: Mass Spectrometry in Biotechnological Process Analysis and Control

  • Editors: Elmar Heinzle, Matthias Reuss

  • DOI: https://doi.org/10.1007/978-1-4757-0169-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1987

  • Softcover ISBN: 978-1-4757-0171-5Published: 03 June 2012

  • eBook ISBN: 978-1-4757-0169-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 241

  • Topics: Mass Spectrometry, Science, Humanities and Social Sciences, multidisciplinary

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