Hormonal Control of the Hypothalamo-Pituitary-Gonadal Axis

1. Front Matter

   Pages i-2

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2. Neuroendocrine Control of Gonadotropin Secretion

   1. Role of Peptides in the Control of Gonadotropin Secretion

      • S. M. McCann, G. D. Snyder, S. R. Ojeda, M. D. Lumpkin, A. Ottlecz, W. K. Samson

      Pages 3-25

   2. Molecular Aspects of the Release of Luteinizing Hormone Releasing Hormone (LHRH) from Hypothalamic Neurons

      • Ayalla Barnea

      Pages 27-38

   3. Role of Peptides in the Regulation of Gonadotropin and Prolactin Secretion

      • M. Motta, P. Falaschi, S. Zoppi, L. Martini

      Pages 39-53

   4. Estrous Cycle Dependent Modulation of Muscarinic Cholinergic Receptors in the Hypothalamus and Adenohypophysis

      • Mordechai Sokolovsky, Ethy Moscona-Amir, Yaakov Egozi

      Pages 55-70

3. Molecular Aspects of GnRH Biosynthesis, Release, and Degreadation

   1. Hormones and other Messenger Molecules: An Approach to Unity

      • Jesse Roth, Derek LeRoith, Joseph Shiloach, Chaim Rabinowitz

      Pages 71-87

   2. Regulation of the Synthesis, Release and Action of Hypothalamic Luteinizing Hormone Releasing Hormone

      • George Fink, Ann Curtis, Val Lyons

      Pages 89-100

   3. Degradation of LH-RH

      • Karl Bauer, Bernhard Horsthemke

      Pages 101-114

   4. Degradation of Luteinizing Hormone-Releasing Hormone by Rat Pituitary Plasma Membrane Associated Enzymes

      • Yitzhak Koch, Stella Elkabes, Mati Fridkin

      Pages 115-126

4. GnRH Receptors and Action in the Pituitary

   1. GnRH Receptors: Identification, Localization and Implications for Biological Function

      • Eli Hazum

      Pages 127-139

   2. Physiological Regulation of Pituitary GnRH Receptors

      • R. N. Clayton, S. I. Naik, L. S. Young, H. M. Charlton

      Pages 141-151

   3. GnRH Receptor Microaggregation: Regulation of Gonadotropin Release, GnRH Receptors, and Gonadotrope Responsiveness

      • P. Michael Conn, Deloris C. Rogers, Sallie G. Seay, Lothar Jennes, Hyder Jinnah, Michael Bates et al.

      Pages 153-167

5. Secretory Processes in the Pituitary

   1. Recent Progress in Cell Biology of Secretory Process in Anterior Pituitary Cells

      • Andrée Tixier-Vidal, Claude Tougard

      Pages 169-180

   2. Fluidity of Gonadotropin Storage in Cycling Female Rats

      • Gwen V. Childs

      Pages 181-198

   3. Regulation of Peptide Hormone Receptors in the Pituitary-Gonadal Axis: Receptors to Gonadotropins and Gonadotropin Releasing Hormone

      • Abraham Amsterdam

      Pages 199-218

6. Gonadotropin Antagonists

   1. Strategies for the Inhibition of Gonadotropin Action

      • M. R. Sairam

      Pages 219-234

   2. The Role of Carbohydrate Moiety of Gonadotropin Molecule in Transduction of Biological Signal

      • Uriel Zor, M. R. Sairam, Pnina Shentzer, Anat Azrad, Abraham Amsterdam

      Pages 235-248

7. Endocrine Regulation of Ovarian Functions

   1. Intraovarian Regulation of Follicular Granulosa Cell Differentiation

      • Joseph Orly, Patricia Weinberger-Ohana, Ronit Shoshani

      Pages 249-261

   2. Calcium: A Cellular Mediator of Luteolysis

      • Harold R. Behrman, Peter J. Albert, Steven D. Gore, Laneta J. Dorflinger

      Pages 263-272

   3. New Perspectives on the Endocrine Regulation of the Rabbit Corpus Luteum

      • P. Landis Keyes, Khe-Ching M. Yuh, Charles H. Bill II, John E. Gadsby

      Pages 273-288

The eleventh monograph and meeting of the Foundation on "Hormon­ al Control of the Hypothalamo-Pituitary-Gonadal Axis" was held in October 1983 at the Weizmann Institute of Science. This monograph honors the memory of Professor Hans R. Lindner, a productive and innovative scientist greatly respected and admired by his col­ leagues. When addressing the opening session I remarked that my impres­ sion of the Weizmann Institute was one or two large buildings hous­ ing the various departments. This was my first visit to Israel and I was overwhelmed by the beautiful semi-tropical gardens of the in­ stitute, in a setting of shrubs and trees, orange groves and flow­ ers. Sited among this seventy-five acres are over fifty buildings and residential areas for the staff and visiting scientists. I saw pictures of this area when Dr. Chaim Weizmann founded in 1934, the Daniel Sieff Research Institute, the forerunner of the Weizmann In­ stitute. The site was sand dunes without a blade of grass. That the desert shall bloom is illustrative of the progress made in Is­ rael. The topics of the monograph are grouped into twelve sections.

• Gonadotropin
• biosynthesis
• hormone
• hormone receptors
• hypothalamus
• memory
• neuropeptides
• prolactin
• research
• steroid
• steroids
• treatment
• diabetes

• International Foundation for Biochemical Endocrinology, Blue Hill Falls, USA

  Kenneth W. McKerns

• Weizmann Institute of Science, Rehovot, Israel

  Zvi Naor

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