Pediatric Liver Disease

1. Front Matter

   Pages i-ix

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2. Developmental Aspects of Liver Structure and Function

   1. Early Development of the Liver: A Review

      • Robert L. Peters

      Pages 1-15

   2. Developmental Aspects of the Hepatic Circulation

      • Ian M. Taylor

      Pages 17-38

   3. Discussion

      • E. Cutz

      Pages 39-42

   4. Developmental Aspects of Bile Acid Metabolism and Hepatic Function

      • John B. Watkins

      Pages 43-53

   5. Hepatic Drug-Metabolizing Enzymes during Embryonic and Fetal Development

      • Allan B. Okey, Daniėl Nebert

      Pages 55-93

   6. Discussion

      • M. M Thaler

      Pages 95-95

3. Cholestatic Liver Disease in Newborns and Infants

   1. A Clinical Approach to Cryptogenic Cholestasis of the Newborn

      • Ross C. deBelle

      Pages 97-103

   2. The Role of Bile Acids in Pediatric Cholestasis

      • Harvey L. Sharp, Deborah K. Freese, Russell F. Hanson

      Pages 105-118

   3. Microfilament Dysfunction in Cholestasis: Possible Involvement in Familial Pediatric Cholestatic Syndromes

      • A. Weber, I. Yousef, B. Tuchweber

      Pages 119-129

   4. Discussion

      • J. L. Weber

      Pages 130-130

   5. Extrahepatic Biliary Atresia: Clinical Aspects

      • Daniel Alagille

      Pages 131-136

   6. Pathology and Pathogenesis of Extrahepatic Biliary Atresia

      • C. L. Witzleben

      Pages 137-145

   7. The Surgery of Biliary Atresia: Current Investigations

      • John R. Lilly, Christine M. L. Pau

      Pages 147-156

   8. Discussion

      • B. Shandling

      Pages 156-160

4. New Developments in Viral Hepatitis

   1. Viral Hepatitis Type A: Redefinition of Virologic, Clinical and Epidemiologic Features

      • Jules L. Dienstag

      Pages 161-173

   2. Discussion

      • D. H. Carver

      Pages 175-175

   3. Viral Hepatitis, Type B

      • Saul Krugman, Wolf Szmuness

      Pages 177-186

   4. Hepatitis Non A Non B: A Newly Recognized Old Disease

      • Harvey J. Alter

      Pages 187-206

   5. Discussion

      • M. M. Fisher

      Pages 207-215

This was an important Symposium in a rapidly developing field of interest. It was designed to draw attention to areas which have been neglected in standard hepatology textbooks and to review areas of controversy. It was also meant to help bridge the communication gap between hepatologists'caring for children and adults as well as between some areas of clinical and basic research. The Symposium was a substantial success. Unfortunately two of the twenty participants did not deliver a manuscript. The result is a publication which is late and which is not as complete as it should be. For this lateness and incompleteness the editors apolo­ gize most sincerely--especially to those participants who delivered their manuscripts on time but even to those who delivered their manu­ scripts late. perhaps the most noteworthy feature of this publication is the fact that material presented in May 1980 is by no means out of date. Apart from the section on Viral Hepatitis, one of the most rapidly evolving fields of medicine, the context of the Symposium remains disturbingly current. The neglect continues, the controversies remain. We hope that this publication will help draw investigators into liver research, provide a useful point of reference for· those in the field and stand as a monument to editors past, present and future, who have chased, are chasing and will chase manuscripts in vain.

• hepatitis
• hepatology
• liver
• liver disease
• viral hepatitis

• Department of Medicine, University of Toronto Sunnybrook Medical Centre, Toronto, Canada

  M. M. Fisher

• Département de Pédiatrie, Université de Montréal Hôpital Sainte-Justine, Montréal, Canada

  C. C. Roy

Policies and ethics