Central Regulation of the Endocrine System

1. Front Matter

   Pages i-xiii

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2. Opening Address

   1. Opening Address

      • Rolf Luft

      Pages 1-2

3. The Peptidergic Neuron

   1. Neuroendocrine Regulation: The Peptidergic Neuron Introduction and Historical Background

      • Charles H. Sawyer

      Pages 3-8

   2. The biochemistry of peptidergic neurons

      1. Hypothalamic Hormones Regulating Pituitary (and Other) Functions: Their Physiology and Biochemistry as Well as Recent Studies with Their Synthetic Analogues

         • A. V. Schally, A. Arimura, D. H. Coy, A. J. Kastin, C. A. Meyers, T. W. Redding et al.

         Pages 9-29

   3. Presynaptic mechanisms in peptidergic neurons

      1. Neurotransmitters and Neuropeptides: Distribution Patterns and Cellular Localization as Revealed by Immunocytochemistry

         • T. Hökfelt, O. Johansson, Å. Ljungdahl, J. Lundberg, M. Schultzberg, K. Fuxe et al.

         Pages 31-48

      2. Activation of Release and Mechanism of Release of Neurohypophyseal Hormones

         • Niels A. Thorn, James T. Russell, Christian Torp-Pedersen, Marek Treiman

         Pages 49-60

      3. Studies on the Release and Degradation of Hypothalamic Releasing Hormones by the Hypothalamus and Other CNS Areas <u>in Vitro</u>

         • S. L. Jeffcoate, N. White, G. W. Bennett, J. A. Edwardson, E. C. Griffiths, R. Forbes et al.

         Pages 61-70

   4. Postsynaptic mechanisms in peptidergic transmission

      1. The Role of GTP in the Coupling of Hormone Receptors and Adenylate Cyclase

         • M. Rodbell, W. Schlegel

         Pages 71-83

      2. Interactions Between Hypothalamic and Peripheral Hormones at the Anterior Pituitary Level

         • F. Labrie, J. Drouin, L. Lagace, L. Ferland, M. Beaulieu, V. Raymond et al.

         Pages 85-107

      3. Peptide and Neurotransmitter Receptors in the Brain: Regulation by Ions and Guanyl Nucleotides

         • Solomon H. Snyder

         Pages 109-117

      4. Neurophysiology of Hypothalamic Peptidergic Neurons

         • L. P. Renaud, Q. J. Pittman, H. W. Blume

         Pages 119-136

      5. The Opioid Receptors and their Ligands

         • Lars Terenius

         Pages 137-148

4. Transmitter and Neuropeptide Synaptic Mechanisms

   1. Regulation of the β-Adrenergic Receptor in the Pineal Gland and Red Cell Membranes

      • Julius Axelrod

      Pages 149-156

   2. Cyclic Nucleotide and Protein Phosphorylation Mechanisms in the Central Nervous System

      • Paul Greengard

      Pages 157-172

   3. Contrasting Principles of Synaptic Physiology: Peptidergic and Non-Peptidergic Neurons

      • Floyd E. Bloom

      Pages 173-187

   4. Regulation of Neuropeptide Release in Rat Brain

      • Leslie L. Iversen, Thomas M. Jessell

      Pages 189-207

   5. Studies on Interactions of Epinephrine Neuronal Systems with other Neuronal Systems

      • M. Goldstein, A. Sauter, F. Hata, J. Y. Lew, Y. Baba, J. Engel et al.

      Pages 209-222

   6. Effect of Peptides on Brain Monoamines and on Gross Behaviour

      • Arvid Carlsson, J. A. Garcia-Sevilla, Tor Magnusson

      Pages 223-238

5. Hormonal Control of Peptidergic Neurons

   1. Current Approaches to Steroid Hormone-Cell Interactions

      • Etienne-Emile Baulieu

      Pages 239-260

   2. Steroid Hormone Receptors in Brain and Pituitary

      • Bruce S. McEwen, Paula G. Davis, Lewis C. Krey, Ivan Lieberburg, Neil MacLusky, Edward Roy

      Pages 261-271

According to the classical concept of Geoffrey Harris the pituitary gland is controlled by the brain by means of blood-borne chemical messengers produced by central neurons. The recent isolation and structural characterization of several such messengers by Roger Guillemin and Andrew Schally and their collaborators brought the final proof for this hypothesis. This also meant that the extensive knowledge collected in the field of neurobiology now became highly relevant for the endocrinologists. For this reason it was felt important to organize a symposium which brought together experts in the fields of neurobiology and endocrinology. The idea was to focus the attention on neuronal mechanisms, particularly those related to chemical transmission, which may be of importance for the central regulation of hormonal secretion patterns. We would like to express our sincere gratitude to the Nobel Founda­ tion for supporting the organization of the Nobel Symposium 42 on "Principles of the Central Regulation of the Endocrine System". We would also like to express our thanks to all participants, to Professor Carl-Gustaf Bernhard, Permanent Secretary of the Royal Academy of Sciences, for making the facilities of the Academ- available to us, and to the Symposium secretaries Mrs. Gun Hultgren, Mrs. Lena Persson and Mrs. Ulla-Britt Wedin. It is a pleasure to acknowledge the generous financial support from the Nobel Foundation and its Nobel Symposium Committee through grants from the Tercentenary Foundation of the Bank of Sweden, and from the Swedish Medical Research Council, KABI AB, Stockholm, and ASTRA AB, Sodertalje.

• attention
• biochemistry
• brain
• nervous system
• neurobiology
• neuroendocrinology
• neurons
• neuropeptides
• neurophysiology
• physiology

• Karolinska Institute, Stockholm, Sweden

  Kjell Fuxe, Tomas Hökfelt, Rolf Luft

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