Mechanisms of Stimulus—Response Coupling in Platelets

1. Front Matter

   Pages i-xi

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2. Platelet Receptors

   1. Structure and Organisation of Platelet Membranes

      • Neville Crawford

      Pages 1-13

   2. Platelet Receptors for Thrombin

      • Thomas C. Detwiler, Eleanor B. McGowan

      Pages 15-28

   3. Characterisation of ADP Receptors

      • Noel J. Cusack, Susanna M. O. Hourani, Laurence A. Welford

      Pages 29-39

   4. Fibrinogen and Platelet Function

      • Gérard A. Marguerie, Mark. H. Ginsberg, Edward F. Plow

      Pages 41-54

   5. Characterisation of Factor VIII Receptors

      • Sandor S. Shapiro

      Pages 55-66

   6. Characterization of Thromboxane Receptors in Human Platelets

      • R. L. Jones, N. H. Wilson, Roma A. Armstrong

      Pages 67-81

   7. Specific Binding of [3H]-1-O-Octadecyl Paf-Acether to Washed Human Platelets

      • D. P. Tuffin, P. Davey, R. L. Dyer, D. O. Lunt, P. J. Wade

      Pages 83-96

   8. Characterisation of Human Platelet Adrenoceptors

      • D. B. Barnett, S. S. Swart, S. R. Nahorski, N. Cook

      Pages 97-108

   9. Specificity Between the Anti-Aggregatory Actions of Prostacyclin, Prostaglandin E1 And D2 on Platelets

      • B. J. R. Whittle, S. Hamid, P. Lidbury, A. C. Rosam

      Pages 109-125

3. Control of Calcium Mobilization

   1. Agonist-Induced Inositol Phospholipid Metabolism and Ca++ Flux in Human Platelet Activation

      • D. Euan MacIntyre, W. Kenneth Pollock, Angus M. Shaw, Mark Bushfield, Linda J. MacMillan, Archibald McNicol

      Pages 127-144

   2. Control and Interrelation of Aggregation and Secretion; the Roles of Ca2+, Diacylglycerol and Thromboxane with Particular Reference to ADP Stimulation

      • T. J. Hallam, A. W. M. Simpson, N. O’Connor, T. J. Rink

      Pages 145-162

   3. Measurement of Intracellular Platelet Calcium with Aequorin and Quin 2

      • Edwin W. Salzman, Peter C. Johnson, J. Anthony Ware

      Pages 163-170

   4. Permeabilised Platelets and Exocytosis

      • Michael C. Scrutton, Derek E. Knight, Verena Niggli

      Pages 171-183

   5. Platelet Membranes, Eicosanoid Biosynthesis and Putative Endogenous Calcium Ionophores

      • F. Carey, S. Menashi, K. S. Authi, N. Hack, M. Lagarde, N. Crawford

      Pages 185-199

   6. Hydrolysis of Cytoskeletal Proteins by the Ca2+-Dependent Protease During Platelet Activation

      • Joan E. B. Fox

      Pages 201-213

4. Phosphorylation of Platelet Proteins and Nucleotide Metabolism

   1. Energy Requirements for Stimulus-Response Coupling

      • Holm Holmsen, Anna Opstvedt Nilsen, Sissel Rongved

      Pages 215-233

   2. Platelet Protein Phosphorylation

      • J. M. Gerrard, L. L. Friesen, J. M. McCrea, S. J. Israels, P. Robinson

      Pages 235-248

   3. Protein Kinase C and Granule Release in Human Platelets

      • M. Castagna, R. Brasseur, C. Pavoine, R. Bredoux, B. Mely, J. M. Ruysschaert et al.

      Pages 249-263

   4. Receptor-Effector Coupling in Platelets: Roles of Guanine Nucleotides

      • Richard J. Haslam, Kimberley A. Williams, Monica M. L. Davidson

      Pages 265-280

Since its inception the research area of platelet pharmacology has always been a vigorous one and it is a characteristic that new approaches to the understanding of platelet function are rapidly and thoroughly investigated. The intensity of this activity is attri­ butable, probably, to an appreciation by research workers in the field that a satisfactory therapeutic control of platelet function has yet to be realized. Also that if and when this problem of con­ trolling platelet function is achieved the benefits to clinical medicine will be immense since platelets are known to be involved in a multiplicity of events coupled within the haemostatic mechanisms and inflammatory responses. Aberrations in the behaviour of plate­ lets is part of the aetiology of atherosclerosis, myocardial and cerebral infarction and thrombosis. At this point in time, research in platelet function is in a particularly rapid state of flux. The recent findings of research workers active in the field and also workers investigating mechan­ isms of stimulus response coupling in other cells, have provided interesting insights into the generality of mechanisms involved in the function of responsive cells. One may itemize these developments as the area of cell receptor/ligand interaction, induction of cell­ ular response by protein phosphorylation and calcium flux. The mech­ anism of these latter events occurs through the activity of phospho­ lipase generating transient intermediates. These intermediates may act as ionophores or enzyme activators or may, in the case of eico­ sanoids, reinforce and make irreversible the cellular response.

• Ether
• Lipid
• Nucleotid
• Protein
• behavior
• cell
• development
• etiology
• inflammatory response
• medicine
• oxygen
• phosphorylation
• platelets
• receptor
• synthesis

• Department of Pharmacology, Royal College of Surgeons, London, England

  J. Westwick

• Thrombosis Research Unit, King’s College School of Medicine and Dentistry, London, England

  M. F. Scully, V. V. Kakkar

• Department of Pharmacology, University of Glasgow, Glasgow, Scotland

  D. E. MacIntyre

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