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  • Book
  • © 1990

Triazenes

Chemical, Biological, and Clinical Aspects

Editors:

  1. Tullio Giraldi

    1. Istituto di Farmacologia, Università di Trieste, Trieste, Italy

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  2. Thomas A. Connors

    1. Toxicology Unit, Medical Research Council, Carshalton, Surrey, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Giuseppe Cartei

    1. Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, Udine, Italy

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-viii
    PDF

  5. Antimestastatic Action of Triazene Derivatives

    • Tullio Giraldi, Laura Perissin, Sonia Zorzet, Valentina Rapozzi
    Pages 45-62

  6. Effects of Triazenes on Immune Responses

    • Stefania D’Atri, Lucio Tentori, Maria Tricarico, Enzo Bonmassar
    Pages 63-77

  7. Xenogenization of Experimental Tumors by Triazene Derivatives

    • Paolo Puccetti, Luigina Romani, Ursula Grohmann, Roberta Bianchi, Patrizia Fuschiotti, Massimo Allegrucci et al.
    Pages 79-89

  8. The Metabolism of Antineoplastic Triazenes

    • Andreas Gescher, Lincoln L. H. Tsang, John A. Slack
    Pages 91-96

  9. Notes on the Metabolism, Pharmacokinetics and Mode of Action of N-Methyl and N-Ethyl-Triazenes in Relation to Their Pharmacological Activity

    • Maurizio D’Incalci, Tina Colombo, Pierluigi Farina Cecilia Mannironi, Pietro Taverna, Carlo V. Catapano
    Pages 97-107

  10. Clinical Use of Triazenes

    • Sándor Eckhardt
    Pages 109-118

  11. Clinical Studies with the p-Carboxyl Dimethyl Phenyl Triazene CB10-277

    • David R. Newell, Brenda J. Foster, James Carmicheal, Adrian L. Harris, Karen Jenns, Lyndsey Gumbrell et al.
    Pages 119-131

  14. O6-Alkylguanine-DNA-Alkyltransferase Gene Expression and the Cytotoxicity of Triazenes

    • G. P. Margison, L. C. Harris, L. Cernakova, V. Vlckova, J. Brozmanova, K. Kleibl et al.
    Pages 161-172

  16. Experimental Background and Early Clinical Studies with Imidazotetrazine Derivatives

    • E. S. Newlands, G. R. P. Blackledge, J. Slack, N. S. A. Stuart, M. F. G. Stevens
    Pages 185-193

  17. O6-Alkylguanine-DNA-Alkyltransferase: Significance, Methods of Measurement and Some Human Tumour and Normal Tissue Levels

    • G. P. Margison, P. J. O’Connor, D. P. Cooper, J. Davies, C. N. Hall, S. M. S. Redmond et al.
    Pages 195-206

  18. Summary of Poster-Sessions

    • E. Bonmassar, A. Gescher, D. R. Newell, M. F. G. Stevens
    Pages 207-211

  19. Back Matter

    Pages 213-227
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Keywords

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Reviews

From Book News, Inc.
A class of antitumor agents is discussed in 16 papers, which include explorations of the synthesis, chemical properties, biotransformation, and pharmacokinetics in animals and humans, and studies of analogous agents and substances affecting the mechanism of triazenes. Specific topics include antimetastatic action, immune responses, xenogenization, clinical use, and therapeutic considerations.
Annotation copyright Book News, Inc. Portland, Or.

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Editors and Affiliations

  • Istituto di Farmacologia, Università di Trieste, Trieste, Italy

    Tullio Giraldi

  • Toxicology Unit, Medical Research Council, Carshalton, Surrey, UK

    Thomas A. Connors

  • Divisione di Oncologia Medica, Ospedale S. Maria della Misericordia, Udine, Italy

    Giuseppe Cartei

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Bibliographic Information

  • Book Title: Triazenes

  • Book Subtitle: Chemical, Biological, and Clinical Aspects

  • Editors: Tullio Giraldi, Thomas A. Connors, Giuseppe Cartei

  • DOI: https://doi.org/10.1007/978-1-4615-3832-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1990

  • Hardcover ISBN: 978-0-306-43667-3Published: 01 January 1991

  • Softcover ISBN: 978-1-4613-6710-9Published: 17 October 2012

  • eBook ISBN: 978-1-4615-3832-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 227

  • Topics: Oncology, Cancer Research, Biochemistry, general

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Buy it now

eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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