The Acth Axis: Pathogenesis, Diagnosis and Treatment

1. Front Matter

   Pages i-xi

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2. Ontogeny of the pituitary corticotroph system

   • Maria Nudi, Éric Batsché, Jacques Drouin

   Pages 1-27

3. Proopiomelanocortin gene expression in man

   • Yves de Keyzer, Marie-Laure Raffin-Sanson, Xavier Bertagna

   Pages 29-45

4. Multifactorial regulation of the corticotroph axis: animal models

   • Katia P. Karalis

   Pages 47-64

5. CRH-Receptors and their Ligands

   • Christina Maier, Harald Kotzmann, Anton Luger

   Pages 65-83

6. ACTH Precursors in Different Pathological Conditions

   • Anne White, David Ray

   Pages 85-107

7. Interactions Between the Hypothalamo-Pituitary-adrenal Axis and the Immunological System

   • Rolf C. Gaillard

   Pages 109-135

8. Pituitary Corticotroph SOCS-3: An Important Regulator of Pomc Gene Expression

   • Christoph J Auernhammer

   Pages 137-152

9. The Melanocortin Pathway and Food Intake

   • Daniel L. Marks, Roger D. Cone

   Pages 153-169

10. The ACTH Receptor and Its Mutations

    • Adrian J. L. Clark, Peter J. King

    Pages 171-190

11. Leptin and the Hypothalamopituitary-Adrenal Axis

    • François P. Pralong, Rolf C. Gaillard

    Pages 191-205

12. Cushing’s Syndrome due to Aberrant Adrenal Hormone Receptors

    • Isabelle Bourdeau, Nina N’Diaye, Hortensia Mircescu, Johanne Tremblay, Pavel Hamet, Ander Lacroix

    Pages 207-228

13. Cushing’s Syndrome - The Diagnosis and Differential Diagnosis

    • Morris Damian, Ashley Grossman

    Pages 229-257

14. Lost and Found: the Pars Intermedia of the Human Pituitary and its Role in the Histogenesis of Silent “Corticotroph” Adenomas.

    • Eva Horvath, Kalman Kovacs

    Pages 259-275

15. Therapeutic Strategies in Cushing’s Disease

    • Maria Alexandra Magiakou, George P. Chrousos

    Pages 277-306

16. Syndromes of Glucocorticoid Resistance

    • Nannette A. T. M. Huizenga, Steven W. J. Steven

    Pages 307-327

17. Back Matter

    Pages 329-338

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"In this outstanding volume, Dr. Gaillard has assembled a team of international experts who have written one of the most comprehensive treatises on this topic. Ranging from fundamental molecular developmental mechanisms of the corticotroph cell, to the treatment of Cushing's Disease, these chapters provide a cutting edge overview of the pathogenesis, diagnosis and treatment of disordered hypothalamic-pituitary-adrenal function. Especially noteworthy are the inclusion of chapters on appetite control and neuro-immunomodulation, reflecting the recent exciting advances in these fields.
The student of Cushing's Disease and the HPA axis will find elucidation of the latest basic scientific advances, coupled with patient friendly guidelines for clinical diagnosis and management of an extremely challenging neuroendocrine disorder. The repute of the authors, highest quality writing, lucid text and comprehensive coverage of the topics, all blend to result in an excellent text."

• ACTH
• glucocorticoid
• hormone
• hormone receptors
• receptor
• diabetes

• Division of Endocrinology, Diabetology & Metabolism, University Hospital (CHUV), Lausanne, Switzerland

  Rolf C. Gaillard

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