High Altitude

1. Front Matter

   Pages i-xi

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2. Cellular and Molecular Mechanisms of O2 Sensing

   • Paul T. Schumacker

   Pages 1-22

3. Cellular and Molecular Defenses Against Hypoxia

   • Stilla Frede, Joachim Fandrey

   Pages 23-35

4. Control of Breathing

   • Luc J. Teppema, Remco R. Berendsen

   Pages 37-55

5. Lung Function and Gas Exchange

   • Andrew M. Luks, Susan R. Hopkins

   Pages 57-83

6. Pulmonary Circulation

   • Marco Maggiorini, Peter Bärtsch, Erik R. Swenson

   Pages 85-102

7. Cardiovascular System

   • Aaron L. Baggish, Eugene E. Wolfel, Benjamin D. Levine

   Pages 103-139

8. Cerebral Circulation and Brain

   • Philip N. Ainslie, Mark H. Wilson, Christopher H. E. Imray

   Pages 141-170

9. Autonomic Nervous System

   • Mark J. Drinkhill, Roger Hainsworth, Victoria E. Claydon

   Pages 171-189

10. Skeletal Muscle Tissue Changes with Hypoxia

    • Hans Hoppeler, Matthias Mueller, Michael Vogt

    Pages 191-202

11. Blood and Haemostasis

    • Peter Bärtsch, Jim S. Milledge

    Pages 203-216

12. Renal Function and Fluid Homeostasis

    • Erik R. Swenson, Niels V. Olsen

    Pages 217-236

13. Endocrine Function

    • Jean-Paul Richalet

    Pages 237-252

14. Gastrointestinal Function

    • Noor Hamad, Simon Travis

    Pages 253-270

15. Immune System

    • Robert S. Mazzeo, Erik R. Swenson

    Pages 271-284

16. Nutrition and Metabolism

    • George A. Brooks

    Pages 285-300

17. Exercise

    • Carsten Lundby

    Pages 301-323

18. Sleep

    • Yvonne Nussbaumer-Ochsner, Konrad E. Bloch

    Pages 325-339

19. Reproduction and Growth

    • Susan Niermeyer

    Pages 341-355

20. Human Evolution at High Altitude

    • Cynthia M. Beall

    Pages 357-377

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Over the last decade the science and medicine of high altitude and hypoxia adaptation has seen great advances. High Altitude: Human Adaptation to Hypoxia addresses the challenges in dealing with the changes in human physiology and the particular medical conditions that arise from exposure to high altitude. In-depth and comprehensive chapters cover both the basic science and the clinical consequences of exposure to high altitude. Genetic, cellular, organ and whole body system responses to high altitudes are covered and chapters discuss these effects on a wide range of diseases. Expert authors provide insight into the care of patients with pre-existing medical conditions that fail in some cases to adapt as well as offer insights into how high altitude research can help critically ill patients. High Altitude: Human Adaptation to Hypoxia is an important new volume that offers a window into greater understanding and more successful treatment of hypoxic human diseases.

• Acute Mountain Sickness
• High Altitude Medicine
• High Altitude and Common Medical Conditions
• Human Adaptation
• Hypoxia

• University of Washington, VA Puget Sound Health Care System, Seattle, USA

  Erik R. Swenson

• Medical University Clinic, Heidelberg, Germany

  Peter Bärtsch

Erik R. Swenson, MD is a professor in the division of Pulmonary and Critical Care Medicine at the University of Washington. His research interests include adaptation and maladaptation in animals and humans to high altitude hypoxia: renal and pulmonary responses with emphasis on acute mountain sickness and high altitude pulmonary edema. Peter Bartsch, MD has participated in many field studies in the Alps, investigating the physiology, prevention and treatment of acute high altitude illnesses. From 1984 to 1989, he ran high altitude research projects at the Inselspital Bern, in co-operation with Oswald Oelz, and in 1990, he led the Exercise Physiology Laboratory at the Swiss School of Sports. In 1991, he was appointed Professor of Sports Medicine at the University of Heidelberg where he is currently the head of the Division of Sports Medicine. Peter Bartsch

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