Overview
Covers pathways of stress-induced mutagenesis in all systems
Serves a wide audience
Examines changed ideas about mutation and evolution
Includes supplementary material: sn.pub/extras
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Table of contents (13 chapters)
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Front Matter
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Back Matter
About this book
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells. The stress-induced mutations occur during growth-limiting stress, and can include adaptive mutations that allow growth in the otherwise growth-limiting environment. The stress responses increase mutagenesis specifically when cells are maladapted to their environments, i.e. are stressed, potentially accelerating evolution then. The mutation mechanism also includes temporary suspension of post-synthesis mismatch repair, resembling mutagenesis characteristic of some cancers. Stress-induced mutation mechanisms may provide important models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and many other important evolutionary processes.
This book covers pathways of stress-induced mutagenesis in all systems. The principle focus is mammalian systems, but much of what is known of these pathways comes from non-mammalian systems.
Editors and Affiliations
Bibliographic Information
Book Title: Stress-Induced Mutagenesis
Editors: David Mittelman
DOI: https://doi.org/10.1007/978-1-4614-6280-4
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media New York 2013
Hardcover ISBN: 978-1-4614-6279-8Published: 10 March 2013
Softcover ISBN: 978-1-4899-9418-9Published: 03 April 2015
eBook ISBN: 978-1-4614-6280-4Published: 12 March 2013
Edition Number: 1
Number of Pages: XV, 275
Topics: Human Genetics, Biochemistry, general, Biomedicine general