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Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

  • Book
  • © 2013

Overview

Editors:
  1. Darren R. Flower

    1. Aston Pharmacy School, School of Life and Health Sciences, University of Aston, Birmingham, United Kingdom

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  2. Yvonne Perrie

    1. Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Will address an important emergent area within immunomics: adjuvants
  • Explores ways to make vaccines more effective
  • There is no such book like this one
  • Includes supplementary material: sn.pub/extras

Part of the book series: Immunomics Reviews: (IMMUN, volume 5)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
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  2. Immunomic Discovery of Adjuvants, Delivery Systems, and Candidate Subunit Vaccines: A Brief Introduction

    • Darren R. Flower, Yvonne Perrie
    Pages 1-11

  3. Bacterial Genomes and Vaccine Design

    • Valeria Cafardi, John L. Telford, Davide Serruto
    Pages 13-37

  4. Identification of Candidate Vaccine Antigens In Silico

    • Darren R. Flower, Matthew N. Davies, Irini A. Doytchinova
    Pages 39-71

  5. Post-genomic Antigen Discovery: Bioinformatical Approaches to Reveal Novel T Cell Antigens of Mycobacterium bovis

    • Martin Vordermeier, Gareth J. Jones, Samantha Sampson, Stephen V. Gordon
    Pages 73-90

  6. Genome-Based Computational Vaccine Discovery by Reverse Vaccinology

    • Yongqun He
    Pages 91-104

  7. Computational Prediction of Protein Subcellular Localization, Genomic Islands, and Virulence to Aid Antigen Discovery

    • Bhavjinder K. Dhillon, Nancy Y. Yu, Fiona S. L. Brinkman
    Pages 105-115

  8. On the Development of Vaccine Antigen Databases: Progress, Opportunity, and Challenge

    • Hifzur Rahman Ansari, Darren R. Flower, Gajendra P. S. Raghava
    Pages 117-130

  9. What Have Dendritic Cells Ever Done for Adjuvant Design? Cellular and Molecular Methods for the Rational Development of Vaccine Adjuvants

    • Alexander D. Edwards
    Pages 131-154

  10. Towards the Systematic Discovery of Immunomodulatory Adjuvants

    • Darren R. Flower
    Pages 155-180

  11. Designing Liposomes as Vaccine Adjuvants

    • Malou Henriksen-Lacey, Yvonne Perrie
    Pages 181-203

  12. Designing Nonionic Surfactant Vesicles for the Delivery of Antigens for Systemic and Alternative Delivery Routes

    • Jitinder Wilkhu, Anil Vangala, Afzal R. Mohammed, Yvonne Perrie
    Pages 205-232

  13. Immune Stimulating Complexes (ISCOMs) and Quil-A Containing Particulate Formulations as Vaccine Delivery Systems

    • S. Hook, T. Rades
    Pages 233-261

  14. Formulation and Characterisation of PLGA Microspheres as Vaccine Adjuvants

    • Daniel J. Kirby, Randip Kaur, Yvonne Perrie
    Pages 263-289

  15. Powder Vaccines for Pulmonary Delivery

    • Tom Jin, Eric Tsao
    Pages 291-301

  16. Back Matter

    Pages 305-314
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Keywords

About this book

This volume will address an important emergent area within the field of immunomics: the discovery of antigens and adjuvants within the context of reverse vaccinology. Conventional approaches to vaccine design and development requires pathogens to be cultivated in the laboratory and the immunogenic molecules within them to be identifiable. Conventional vaccinology is no longer universally successful, particularly for recalcitrant pathogens. By using genomic information we can study vaccine development in silico: 'reverse vaccinology', can identify candidate subunits vaccines by identifying antigenic proteins and by using equally rational approaches to identify novel immune response-enhancing adjuvants.

Editors and Affiliations

  • Aston Pharmacy School, School of Life and Health Sciences, University of Aston, Birmingham, United Kingdom

    Darren R. Flower

  • Aston Pharmacy School, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom

    Yvonne Perrie

About the editors

Dr. Darren R Flower. An interdisciplinary scientist, with special interest in bioinformatics, computational chemistry, and cheminformatics, Dr. Flower has wide-ranging experience of the pre-clinical research environment in both academia and the pharmaceutical industry. Before joining Aston University as a Reader, Dr. Flower was a Jenner Research Fellow and Principal Investigator at the University of Oxford; and formerly a Senior Group Leader managing a large research group at The Edward Jenner Institute for Vaccine Research. Before that, Dr. Flower was a drug discovery scientist in the Pharmaceutical industry. Dr. Flower is a Fellow of the Royal Society of Chemistry, and the author of over 150 research papers and reviews, and 7 Books, including the monograph: Bioinformatics for Vaccinology.

Professor Yvonne Perrie is Pharmacist whose research focuses on the development on delivery systems for drugs and vaccines. Prof. Perrie is currently Head of Pharmacy and Chair in Drug Delivery within Aston University.  Prof. Perrie received her Ph.D. from the University of London, UK where she investigated the use of liposomes for gene delivery under the supervision of Professor Gregory Gregoriadis. Prof. Perrie then joined a newly established Drug Delivery Company, Lipoxen Technologies Ltd., prior to taking her post at Aston University. Prof. Perrie is currently Chair of the UK and Ireland Controlled Release Society and has approximately 100 research papers and reviews focusing on the research and development of drug delivery systems.

Bibliographic Information

  • Book Title: Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines

  • Editors: Darren R. Flower, Yvonne Perrie

  • Series Title: Immunomics Reviews:

  • DOI: https://doi.org/10.1007/978-1-4614-5070-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2013

  • Hardcover ISBN: 978-1-4614-5069-6Published: 07 December 2012

  • Softcover ISBN: 978-1-4899-9795-1Published: 28 January 2015

  • eBook ISBN: 978-1-4614-5070-2Published: 09 December 2012

  • Series ISSN: 2628-5789

  • Series E-ISSN: 2628-5797

  • Edition Number: 1

  • Number of Pages: X, 314

  • Topics: Immunology, Bioinformatics, Vaccine, Pharmacology/Toxicology

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