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  • © 2011

Epigenetic Contributions in Autoimmune Disease

  • Overview of some of the key concepts in epigenetics, chromatin and the interaction with transcription factors
  • Shows the specific influence of environmental factors to influence or trigger the autoimmune response
  • Discusses the possibilities of using epigenetics-based therapies in the context of autoimmune diseases
  • Presents the application of novel methods to characterize the epigenetic profile

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 711)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvi
  2. An Introduction to Epigenetics

    • Esteban Ballestar
    Pages 1-11
  3. Chromatin Mechanisms Regulating Gene Expression in Health and Disease

    • Constanze Bonifer, Peter N. Cockerill
    Pages 12-25
  4. Epigenetic Control of Lymphocyte Differentiation

    • Eduardo Lopez-Granados
    Pages 26-35
  5. Epigenetic Control in Immune Function

    • Peter J. van den Elsen, Marja C. J. A. van Eggermond, Rutger J. Wierda
    Pages 36-49
  6. DNA Methylation and B-Cell Autoreactivity

    • Soizic Garaud, Pierre Youinou, Yves Renaudineau
    Pages 50-60
  7. Environmental Agents and Autoimmune Diseases

    • Frederick W. Miller
    Pages 61-81
  8. Epigenetic Dysregulation of Epstein-Barr Virus Latency and Development of Autoimmune Disease

    • Hans Helmut Niller, Hans Wolf, Eva Ay, Janos Minarovits
    Pages 82-102
  9. Does Genomic Imprinting Play a Role in Autoimmunity?

    • Cristina Camprubí, David Monk
    Pages 103-116
  10. A New Epigenetic Challenge: Systemic Lupus Erythematosus

    • Biola M. Javierre, Bruce Richardson
    Pages 117-136
  11. Epigenetic Deregulation in Rheumatoid Arthritis

    • Emmanuel Karouzakis, Renate E. Gay, Steffen Gay, Michel Neidhart
    Pages 137-149
  12. Prospects for Epigenetic Compounds in the Treatment of Autoimmune Disease

    • Nadine Chapman-Rothe, Robert Brown
    Pages 150-161
  13. Profiling Epigenetic Alterations in Disease

    • José Ignacio Martín-Subero, Manel Esteller
    Pages 162-177
  14. Back Matter

    Pages 179-182

About this book

This volume focuses on the relevance of epigenetic mechanisms in autoimmune disease. It provides new directions for future research in autoimmune disease.

Editors and Affiliations

  • Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain

    Esteban Ballestar

About the editor

ESTEBAN BALESTAR is head of the Chromatin and Disease Group at the Cancer Epigenetics and Biology Programme (PEBC) of the Bellvitge Biomedical Research Institute (IDIBELL ) in Barcelona, Spain. Ballestar obtained his PhD degree from the University of Valencia under the supervision of Prof. Luis Franco, specialising in chromatin and histone modifications (1997). He then worked as a Postdoctoral Fellow at the National Institutes of Health, (Bethesda, MD, USA) in the laboratory of Dr. Alan Wolffe where he investigated associations between elements of the chromatin machinery and methylated DNA. From 2001 to 2008, Esteban Ballestar has worked at the CNIO Cancer Epigenetics Laboratory, in association with Dr. Manel Esteller, where his principal area of research has been the study of the implication of chromatin factors in epigenetic alterations in human cancer. His current research is devoted to the establishment of different mechanisms of epigenetic deregulation in the context of the hematopoietic system in both autoimmune diseases and hematological malignancies.

Bibliographic Information

  • Book Title: Epigenetic Contributions in Autoimmune Disease

  • Editors: Esteban Ballestar

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4419-8216-2

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2011

  • Hardcover ISBN: 978-1-4419-8215-5Published: 16 February 2011

  • eBook ISBN: 978-1-4419-8216-2Published: 16 February 2011

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 182

  • Topics: Biomedicine general, Gene Function

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access