Histamine in Inflammation

1. Front Matter

   Pages i-xviii

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2. One Hundred Years of Histamine Research

   • Katherine Figueroa, Nigel Shankley

   Pages 1-9

3. Molecular Pharmacology of the Four Histamine Receptors

   • Gerold Bongers, Iwan de Esch, Rob Leurs

   Pages 11-19

4. Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient Mice

   • Hiroshi Ohtsu

   Pages 21-31

5. Histamine in Allergic Rhinitis

   • Thomas Taylor-Clark

   Pages 33-41

6. The Role of Histamine in Ocular Allergy

   • Masaharu Ohbayashi, Bita Manzouri, Kei Morohoshi, Ken Fukuda, Santa J. Ono

   Pages 43-52

7. The Role of Histamine in Asthma

   • Paul J. Dunford, Stephen T. Holgate

   Pages 53-66

8. Antihistamines in the Treatment of Urticaria

   • Torsten Zuberbier, Marcus Maurer

   Pages 67-72

9. Histamine and Antihistamines in Atopic Dermatitis

   • Jörg Buddenkotte, Marcus Maurer, Martin Steinhoff

   Pages 73-80

10. Histamine, Immune Cells and Autoimmunity

    • Elke Schneider, Maria Leite-de-Moraes, Michel Dy

    Pages 81-94

11. Histamine in Neurotransmission and Brain Diseases

    • Saara Nuutinen, Pertti Panula

    Pages 95-107

12. Histamine in Normal and Malignant Cell Proliferation

    • Andras Falus, Zoltán Pós, Zsuzsanna Darvas

    Pages 109-123

13. The Future Antihistamines: Histamine H3 and H4 Receptor Ligands

    • Fuqu Yu, Pascal Bonaventure, Robin L. Thurmond

    Pages 125-140

14. Back Matter

    Pages 141-143

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The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.

• Histamine
• Thurmond
• immunity
• inflammation
• pharmacology
• tissue

• Johnson & Johnson Pharmaceutical Research & Development, LLC, San Diego, USA

  Robin L. Thurmond

Robin L. Thurmond, PhD is a Compound Development Team Leader with the Clinical Research group at Johnson & Johnson Pharmaceutical Research & Development in La Jolla, California. Prior to that he was a Research Fellow with the Immunology Drug Discovery group at the same site. He received his BA in Chemistry from the University of Virginia and his PhD in Biochemistry from the University of Arizona. Dr. Thurmond studied membrane biophysics at the University of Arizona and worked on the molecular aspects of rhodopsin function during his postdoctoral training at the Massachusetts Institute of Technology with Dr. Gobind Khorana. He began his career with Johnson & Johnson in 1996 at the RW Johnson Pharmaceutical Research Institute in Raritan, New Jersey, and has been with Johnson & Johnson for over 14 years. Dr. Thurmond currently resides in San Diego, California.

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