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  • © 2012

Genetically Engineered Mice for Cancer Research

design, analysis, pathways, validation and pre-clinical testing

  • Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches
  • This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology
  • Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials
  • Includes supplementary material: sn.pub/extras

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xx
  2. Overview of Designing Genetically Engineered Mouse (GEM) Models

    • Thomas Doetschman, L. Philip Sanford
    Pages 1-15
  3. The RCAS/TVA Somatic Gene Transfer Method in Modeling Human Cancer

    • Yi Li, Andrea Ferris, Brian C. Lewis, Sandra Orsulic, Bart O. Williams, Eric C. Holland et al.
    Pages 83-111
  4. Target-Selected ENU Mutagenesis to Develop Cancer Models in the Rat

    • Bart M. G. Smits, Edwin Cuppen, Michael N. Gould
    Pages 113-131
  5. Imaging Mouse Models of Human Cancer

    • Jennifer A. Prescher, Christopher H. Contag
    Pages 235-260
  6. Identifying Mammary Epithelial Stem and Progenitor Cells

    • Andrew O. Giacomelli, Robin M. Hallett, John A. Hassell
    Pages 261-279
  7. Differentiation Programs in Development and Cancer

    • Hosein Kouros-Mehr
    Pages 281-292
  8. Mouse Models for Colorectal Cancer

    • Melanie Kucherlapati, Ken Hung, Mari Kuraguchi, Raju Kucherlapati
    Pages 309-329
  9. Src Family Tyrosine Kinases: Implications for Mammary Tumor Progression

    • Richard Marcotte, William J. Muller
    Pages 331-352
  10. Maspin and Suppression of Tumor Metastasis

    • Lauren Reinke, Ming Zhang
    Pages 353-373
  11. Epigenetic Mouse Models

    • Cecilia Rosales, Manel Esteller
    Pages 375-396
  12. Modeling Transforming Growth Factor-ß Signaling in Cancer

    • Veronica R. Placencio, Neil A. Bhowmick
    Pages 397-415

About this book

Genetically-engineered mouse models for cancer research have become invaluable tools for studying cancer biology and evaluating novel therapeutic approaches. This volume focuses on state-of-the-art methods for generating, analyzing and validating such models for studying aspects of human cancer biology. Additionally, these models are emerging as important pre-clinical systems in which to test cancer prevention and therapeutic strategies in order to select compounds for testing in clinical trials.

Editors and Affiliations

  • , Laboratory Of Cancer Biology and Genetic, National Cancer Institute, Bethesda, USA

    Jeffrey E. Green

  • National Cancer Institute, Center for Cancer Research, National Institutes of Health, Bethesda, USA

    Thomas Ried

Bibliographic Information

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access