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Cancer Gene Therapy

Past Achievements and Future Challenges

  • Book
  • © 2002

Overview

Editors:
  1. Nagy A. Habib

    1. Imperial College School of Medicine, Hammersmith Hospital, London, UK

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 465)

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Table of contents (41 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. The Clinical Problem

    1. Management Problems in Oncology

      • Susan J. Cleator, Pat Price
      Pages 3-10

  3. Vectors

    1. Adenoviral Vectors

      • Prem Seth
      Pages 13-22

    2. Retrovirus Vectors

      • Yasuhiro Takeuchi, Massimo Pizzato
      Pages 23-35

    3. Targetable Gene Delivery Vectors

      • Paul L. Hallenbeck, Susan C. Stevenson
      Pages 37-46

    4. Human α-fetoprotein Transcriptional Regulatory Sequences

      • Taiki Tamaoki
      Pages 47-56

    5. Tumor-Targeted Salmonella

      • David Bermudes, Brooks Low, John Pawelek
      Pages 57-63

    6. Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells

      • Makoto Sunamura
      Pages 65-71

    7. Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy

      • Nina Krauzewicz, Beverly E. Griffin
      Pages 73-82

    8. Cochleates

      • Leila Zarif, Raphael J. Mannino
      Pages 83-93

    9. The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer

      • Stephen Coe, Michael Harron, Marc Winslet, Geoffrey Goldspink
      Pages 95-111

  4. Cell Cycle Control

    1. Adhesion Molecules in Cancer Biology

      • Yaw Ohene-Abuakwa, Massimo Pignatelli
      Pages 115-126

    2. Cell Cycle Control

      • Vivien J. Tannoch, Phil W. Hinds, Li-Huei Tsai
      Pages 127-140

  5. Apoptosis

    1. Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death

      • Gen Sheng Wu, Kunghong Kim, Wafik S. El-Deiry
      Pages 143-151

    2. Apoptin®

      • Alexandra Pietersen, Mathieu H. M. Noteborn
      Pages 153-161

    3. Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors

      • Anu-Maaria Sandmair, Matti Vapalahti, Seppo Ylä-Herttuala
      Pages 163-170

    4. Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer

      • M. C. Hung, Hortobagyi G. N., N. T. Ueno
      Pages 171-180

  6. Tumout Suppressor Genes

    1. Pre-clinical Studies with Tumor Suppressor Genes

      • Prem Seth
      Pages 183-192

    2. Gene Therapy for Liver Tumours

      • Ragai R. Mitry, Marc R. Mansour, Roman Havlik, Nagy A. Habib
      Pages 193-205

    3. Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer

      • Junzo Kigawa, Naoki Terakawa
      Pages 207-214
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Keywords

About this book

With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

Editors and Affiliations

  • Imperial College School of Medicine, Hammersmith Hospital, London, UK

    Nagy A. Habib

Bibliographic Information

  • Book Title: Cancer Gene Therapy

  • Book Subtitle: Past Achievements and Future Challenges

  • Editors: Nagy A. Habib

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/b113267

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2002

  • Hardcover ISBN: 978-0-306-46191-0Published: 30 April 2000

  • Softcover ISBN: 978-1-4757-7370-5Published: 14 March 2013

  • eBook ISBN: 978-0-306-46817-9Published: 11 April 2006

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 496

  • Topics: Oncology, Human Genetics, Immunology, Animal Anatomy / Morphology / Histology

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