Abstract
In order to examine possible long-term effects of neonatal hyperthyroidism on catecholamine (CA) neural systems, mice receiving saline or thyroxine injections during the neonatal period were subsequently injected with d-amphetamine or saline immediately prior to testing for locomotor activity at 100 days of age. Thyroxine-treated males were more active than control males following amphetamine injections, but thyroxine-treated and control females did not differ in this regard. In general, the results suggest that neonatal hyperthyroidism may have long-lasting effects on CA function that, at least at the age tested, may be limited to the male mouse.
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Askew, B. M. Hyperpyrexia as a contributing factor in the toxicity of amphetamine to aggregated mice. British Journal of Pharmacology, 1962, 19, 245–257.
Coville, P. F., & Telford, J. M. The effect of thyroid hormones on the action of some centrally acting drugs. British Journal of Pharmacology, 1970, 40, 747–758.
Davenport, J. W., & Gonzalez, L. M. Neonatal thyroxine stimulation in rats: Accelerated behavioral maturation and subsequent learning deficit. Journal of Comparative and Physiological Psychology, 1973, 85, 397–408.
Eayrs, J. T. Effects of neonatal hyperthyroidism on maturation and learning in the rat. Animal Behaviour, 1964, 12, 195–199.
Eayrs, J. T. Thyroid and developing brain: Anatomical and behavioral effects. In M. Hamburgh & E. J. W. Barrington (Eds.), Hormones in development. New York: Appleton-Century-Crofts, 1971.
Emlen, W., Segal, D. S., & Mandell, A. J. Thyroid state: Effects on pre- and postsynaptic central noradrenergic mechanisms. Science, 1972, 175, 79–82.
Enostrom, G., Svensson, T. H., & Waldeck, B. Thyroxine and brain catecholamines: Increased transmitter synthesis and increased receptor sensitivity. Brain Research, 1974, 77, 471–483.
Geel, S. E., & Timiras, P. S. Influence of hypothyroidism and of thyroxine on the acetylcholinesterase and cholinesterase activities of the developing central nervous system of the rat. Endocrinology, 1967, 80, 1069–1074.
Halpern, B. N., & Drudi-Baracco, C., & Bessirard, D. Exaltation of toxicity of sympathomimetic amines by thyroxine. Nature, 1964, 204, 387–388.
Ito, J. M., Valcana, T., & Timiras, P. S. Effect of hypo-and hyperthroidism on regional monoamine metabolism in the adult rat brain. Neuroendocrinology, 1977, 24, 55–64.
Murphy, J. M., & Nagy, Z. M. Neonatal thyroxine stimulation accelerates the maturation of both locomotor and memory processes in mice. Journal of Comparative and Physiological Psychology, 1976, 90, 1082–1091.
Rastogi, R. B., & Singhal, R. L. Neonatal hyperthyroidism: Alterations in behavioral activity and the metabolism of brain norepinephrine and dopamine. Life Sciences, 1976, 18, 351–358.
Salas, M., Diaz, S., & Cintra, L. Electrocortical effects of early postnatal thyroxine administration in the rat. Physiology & Behavior, 1976, 17, 239–244.
Schapiro, S. Some physiological, biochemical, and behavioral consequences of neonatal hormone administration: Cortisol and thyroxine. General and Comparative Endocrinology, 1968, 10, 214–228.
Schapiro, S. Hormonal and environmental influences on rat brain development and behavior. In M. B. Sterman, D. J. McGinty, & A. M. Adinolfi (Eds.), Brain development and behavior. New York: Academic Press, 1971.
Schapiro, S., Vukovich, K., & Globus, A. Effects of neonatal thyroxine and hydrocortisone administration on the development of dendritic spines in the visual cortex of rats. Experimental Neurology, 1973, 40, 286–296.
Winer, B. J. Statistical principles in experimental design (2nd ed.). New York: McGraw-Hill, 1971.
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This research was supported by a grant from the National Institute of Child Health and Human Development (HD-09145) to Z. Michael Nagy. J. M. Murphy is now at the Institute for Psychiatric Research, Indiana University Medical Center, Indianapolis, Indiana.
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Forster, M.J., Nagy, Z.M. & Murphy, J.M. Potentiation of amphetamine-induced hyperactivity in the adult mouse following neonatal thyroxine administration. Bull. Psychon. Soc. 18, 337–339 (1981). https://doi.org/10.3758/BF03333645
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DOI: https://doi.org/10.3758/BF03333645