Abstract
Hippocampally ablated, cortically damaged, and intact control rats were trained postoperatively on a discrete-trial, go, no-go brightness discrimination task in an operant situation. The hippocampally ablated animals were found to be deficient on acquisition primarily due to inappropriate responding on no-go (nonieinforced) trials. The deficit is consistent with other operant brightness discrimination studies, but contrasts with the facilitated go, no-go alternation performance exhibited by hippocampally damaged rats.
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Brown, T. S., Kaufman, P. G., & Marco, L. A. The hippocampus and response preservation in the cat. Brain Research, 1969, 12, 86–98.
Buerger, A. A. Effects of preoperative training on relearning a successive discrimination by cats with hippocampal lesions. Journal of Comparative & Physiological Psychology, 1970, 72, 462–466.
Ireland, L., & Isaacson, R. L. Reactivity in the hippocampectomized gerbil. Psychonomic Science, 1968, 12, 163–164.
Isaacson, R. L., Douglas, R. S., & Moore, R. Y. The effect of radical hippocampal ablation on acquisition of avoidance response. Journal of Comparative & Physiological Psychology, 1961, 54, 625–628.
Kimble, D. P. The effects of bilateral hippocampal lesions in rats. Journal of Comparative & Physiological Psychology, 1963, 56, 273–283.
Means, L. W., Walker, D. W., & Isaacson, R. L. Facilitated single alternation go, no-go performance following hippocampectomy in the rat. Journal of Comparative & Physiological Psychology, 1970, 22, 278–285.
Niki, H. The effects of hippocampal ablation on the inhibitory control of operant behavior in the rat. Japanese Psychological Research, 1965, 7, 126–137.
Rabe, A. Discrimination reversal deficit from hippocampal stimulation in the rat. Journal of Psychological Studies, 1963, 14, 139–150.
Raphelson, A. C., Isaacson, R. L., & Douglas, R. J. The effect of distracting stimuli on the runway performance of limbic damaged rats. Psychonomic Science, 1965, 3, 483–484.
Silveira, J. M., & Kimble, D. P. Brightness discrimination and reversal in hippocampally lesioned rats. Physiology & Behavior, 1968, 3, 625–630.
Walker, D. W., Means, L. W. & Isaacson, R. L. The effects of hippocampal and cortical lesions on single alternation go, no-go acquisition in rats. Psychonomic Science, 1970, 21, 29–31.
Walker, D. W., Messer, L. G., Freund, G., & Means, L. W. The effect of hippocampal lesions and intertrial interval on single alternation performance in the rat. Journal of Comparative & Physiological Psychology, 1972, in press.
Wickelgren, W. O., & Isaacson, R. L. Effects of introduction of an irrelevant stimulus on runway performance of the hippocampectomized rat. Nature, 1963, 200, 48–50.
Woodruff, M. L., & Isaacson, R. L. Discrimination learning in animals with lesions of hippocampus. Behavioral Biology, 1972, 7, 489–501.
Woodruff, M. L., Schneiderman, B., & Isaacson, R. L. Impaired acquisition of a simultaneous brightness discrimination by cortically and hippocampally damaged rats. Psychonomic Science, 1972, 27, 269–271.
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This research was supported in part by NIMH Grant 16384-03 to R. L. Isaacson and by USPHS Training Grant MH-10320 to the Center for Neurobiological Sciences, University of Florida. The authors wish to thank Mrs. Pauletta Sanders for her excellent histological work and Mr. David Clampitt for his assistance with the behavioral testing.
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Woodruff, M.L., Means, L.W. & Isaacson, R.L. Deficient go, no-go brightness discrimination in rats following hippocampal lesions. Psychobiology 1, 85–88 (1973). https://doi.org/10.3758/BF03326874
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DOI: https://doi.org/10.3758/BF03326874