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Oral Ciprofloxacin Affects the Pharmacokinetics of Paracetamol in Saliva

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Abstract

Background: To determine whether concomitant administration of ciprofloxacin has any effect on the release and absorption of paracetamol.

Methods and design: Ten healthy female volunteers received a single oral dose of paracetamol 1g or paracetamol 1g plus ciprofloxacin 500mg in a double-blind, crossover study. Pharmacokinetic parameters were measured in salivary samples using a colorimetric method.

Results: Maximum paracetamol concentration (Cmax) in saliva was significantly decreased when co-administered with ciprofloxacin (19.50 vs 13.70 μg/mL, p < 0.05). Time to paracetamol Cmax was significantly increased (1.43h vs 0.77h; p < 0.05) and paracetamol half-life was prolonged (1.19 to 1.53h, p = 0.05) in the presence of ciprofloxacin, whereas the area under the concentration-time curve was not affected.

Conclusion: Concomitant administration of ciprofloxacin with paracetamol may result in a delayed onset of action of paracetamol.

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Acknowledgements

The authors thank the Palestinian Ministry of Health for their clinical monitoring and Al-Aqsa University for providing the materials. The authors have provided no information on any sources of funding that were used in conducting the study or on any potential conflicts of interest that they may have that are directly relevant to the contents of this study.

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Authors and Affiliations

  1. Department of Chemistry, Pharmaceutical Analytical Chemistry, Alaqsa University, PO Box 4051, Gaza, Palestine, Palestine

    Mahmoud Mohamed Issa

  2. Department of Chemistry, Analytical Chemistry, Alaqsa University, Gaza, PO Box 4051, Palestine, Palestine

    R’afat Mahmoud Nejem

  3. Department of Chemistry, Organic Chemistry, Alaqsa University, Gaza, Palestine, Palestine

    Naser Said El-Abadla

Authors
  1. Mahmoud Mohamed Issa
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  2. R’afat Mahmoud Nejem
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  3. Naser Said El-Abadla
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Correspondence to R’afat Mahmoud Nejem.

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Issa, M.M., Nejem, R.M. & El-Abadla, N.S. Oral Ciprofloxacin Affects the Pharmacokinetics of Paracetamol in Saliva. Clin. Drug Investig. 26, 223–226 (2006). https://doi.org/10.2165/00044011-200626040-00007

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  • DOI: https://doi.org/10.2165/00044011-200626040-00007

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