Skip to main content
Log in

Lamotrigine as maintenance therapy in bipolar I disorder exerts beneficial effects predominantly on the depressive phase

  • Drugs and Profile Reports
  • Published:
Drugs & Therapy Perspectives Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig
Fig
CGI-I
Table 1

Notes

  1. The use of tradenames is for product identification purposes only and does not imply endorsement.

References

  1. Goldsmith DR, Wagstaff AJ, Ibbotson T, et al. Lamotrigine: a review of its use in bipolar disorder. Drugs 2003; 63 (19): 2029–50.

    Article  PubMed  CAS  Google Scholar 

  2. Malhi GS, Mitchell PB, Salim S. Bipolar depression: management options. CNS Drugs 2003; 17 (1): 9–25.

    Article  PubMed  CAS  Google Scholar 

  3. Strakowski SM, DelBello MP, Adler CM. Comparative efficacy and tolerability of drug treatments for bipolar disorder. CNS Drugs 2001; 15 (9): 701–18.

    Article  PubMed  CAS  Google Scholar 

  4. Hirschfeld RMA, Bowden CL, Gitlin MJ, et al. Practice guideline for the treatment of patients with bipolar disorder (revision). Am J Psychiatry 2002 Apr; 159 (4 Suppl.): 1–50

    Google Scholar 

  5. Calabrese JR, Bowden CL, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 2003 Sep; 64 (9): 1013–24.

    Article  PubMed  CAS  Google Scholar 

  6. Bowden CL, Calabrese JR, Sachs G, et al. A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 2003 Apr; 60 (4): 392–400.

    Article  PubMed  CAS  Google Scholar 

  7. Calabrese JR, Bowden CL, Fieve R, et al. Lamotrigine or lithium in the maintenance treatment of bipolar I disorder [abstract no. P.1. 115]. Eur Neuropsychopharmacol 2002; 12 Suppl. 3: S217.

    Google Scholar 

  8. Calabrese JR, Suppes T, Bowden CL, et al. A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 2000 Nov; 61 (11): 841–50.

    Article  PubMed  CAS  Google Scholar 

  9. Calabrese JR, Bowden CL, Sachs GS, et al. A double-blind placebo-controlled study of lamotrigine monotherapy in outpatients with bipolar I depression. J Clin Psychiatry 1999 Feb; 60 (2): 79–88.

    Article  PubMed  CAS  Google Scholar 

  10. Frye MA, Ketter TA, Kimbrell TA, et al. A placebo-controlled study of lamotrigine and gabapentin monotherapy in refractory mood disorders. J Clin Psychopharmacol 2000 Dec; 20 (6): 607–14.

    Article  PubMed  CAS  Google Scholar 

  11. Prescribing information: Lamictal (lamotrigine) [online]. Available from URL: http://us.gsk.com/products/assets/uslamictal.pdf [Accessed 2003 Nov 20]

  12. Ginsberg L, Sachs G, Ketter T, et al. Effects of mood stabilizers on body weight in bipolar I disorder [abstract no. NR463 plus poster]. American Psychiatric Association 2003 Annual Meeting: New Research Abstracts; 2003 May 17, 4

  13. Calabrese JR, Sullivan JR, Bowden CL, et al. Rash in multicenter trials of lamotrigine in mood disorders: clinical relevance and management. J Clin Psychiatry 2002 Nov; 63 (11): 1012–9.

    Article  PubMed  Google Scholar 

Download references

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lamotrigine as maintenance therapy in bipolar I disorder exerts beneficial effects predominantly on the depressive phase. Drugs Ther. Perspect 20, 1–4 (2004). https://doi.org/10.2165/00042310-200420030-00001

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.2165/00042310-200420030-00001

Keywords

Navigation