Abstract
Objective
The purpose of this meta-analysis was to explore the effect of corticosteroids on atrial fibrillation (AF) following catheter ablation.
Methods
We searched PubMed, Embase, and the Cochrane Central Register of Controlled Trials for published articles describing the effect of corticosteroids in preventing AF recurrence after catheter ablation. Data on study and patient were extracted. Risk ratios (RRs) and 95% confidence intervals (CIs) were calculated by use of a random-effect model, and P values of <0.05 were considered significant.
Results
Two randomized controlled trials (RCTs) and three cohort studies involving 846 patients were included in this meta-analysis. Within one month of catheter ablation, corticosteroid use was associated with a declined risk of recurrence of AF in RCT (RR 0.57, 95% CI 0.39 to 0.85, P=0.005), but without significant effect in cohort studies (RR 1.01, 95% CI 0.79 to 1.30, P=0.94). After three months of catheter ablation, corticosteroids did not have a significant effect in the prevention of late recurrence of AF in either RCT (RR 0.78, 95% CI 0.38 to 1.59, P=0.49) or cohort studies (RR 0.96, 95% CI 0.70 to 1.31, P=0.78).
Conclusions
Our meta-analysis suggested that periprocedural administration of corticosteroids of catheter ablation was associated with reduction of early but not late recurrence of AF.
摘要
目的
探讨皮质类固醇对导管消融术后心房颤动(AF)的影响。
创新点
首个探讨皮质类固醇对导管消融术后AF 影响的 荟萃分析。
方法
我们在PubMed、Embase 和Cochrane 对照试验中 心注册库中搜索了描述皮质类固醇对预防导管 消融后AF 复发影响的文章,并提取了研究和患 者的相关数据。使用随机效应模型计算风险比 (RR)和95%置信区间(CI),P<0.05 被认为 具有统计学差异。
结论
导管消融术围术期皮质类固醇的使用与AF 早期 复发减少相关,但与晚期复发无关。
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Jaiswal, S., Liu, Xb., Wei, Qc. et al. Effect of corticosteroids on atrial fibrillation after catheter ablation: a meta-analysis. J. Zhejiang Univ. Sci. B 19, 57–64 (2018). https://doi.org/10.1631/jzus.B1600529
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DOI: https://doi.org/10.1631/jzus.B1600529