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Phytochemical composition, biological potential and enzyme inhibition activity of Scandix pecten-veneris L.

Scandix pecten-veneris L.的植物素、生物学潜力 及酶抑制活性研究

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Abstract

Objective

Scandix pecten-veneris L. is a less studied wild edible herb and is considered an extinct plant species in many parts of the world. This study was designed to evaluate its phytochemical composition and biological potential of S. pecten-veneris L.

Methods

Phytochemicals including alkaloids, flavonoids, polyphenols, and tannins were determined in extracts of S. pecten-veneris. Antioxidant activity was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), while reducing power was tested by ferric reducing/antioxidant power (FRAP) assay. Antimicrobial activity against seven bacterial and four fungal strains was evaluated using agar well diffusion assay. Enzymes inhibition study was performed for urease, phosphodiesterase-I, and catalase-II.

Results

S. pecten-veneris showed moderate antiradical activity and reducing potential of hydroxyl radicals to about 20% of the initial value. The antioxidant activity of various extracts of S. pecten-veneris showed a linear correlation with total phenolic contents in the order of water>n-butanol>chloroform>ethyl acetate>methanol extracts. S. pecten-veneris leaves showed the highest inhibitory activity against Staphylococcus aureus while the highest antifungal activity was observed against Candida albicans. The plant extract was most potent against urease enzymes but showed moderate activity against phosphodiestrase-I and carbonic anhydrase-II.

Conclusions

Our data demonstrate that in addition to its culinary uses, S. pecten-veneris has good medicinal potential and hence could be used for treating some specific health ailments.

概要

目的

本研究旨在测定Scandix pecten-veneris L.的植物 素和评价其生物学潜力。

方法

测定S. pecten-veneris 提取物中植物素的含量, 包括生物碱、黄酮、多酚和单宁。使用2,2-二苯 基-1-苦肼基(DPPH)测 定抗氧化活性;同时通 过铁还原/抗氧化能力(FRAP)测定还原能力; 使用琼脂扩散测定法评价对七种细菌和四种真 菌菌株的抗微 生物活性。同时,对脲酶、磷酸二 酯酶-I 和过氧化氢酶-II 进行酶抑制研究。

结论

沙门氏菌显示出适度的抗自由基活性;羟基自由 基的潜能降至初始值的20%左右。S. pectenveneris 多种提 取物的抗氧化活性与总酚含量呈 线性相关。S. pecten-veneris 叶对金黄色葡萄球菌 表现出最高的抑制活性 ;对白色念珠菌表现出到 最高的抗真菌活性。植物提取物对脲酶的活性最 有效;对磷酸二酯酶-I和 碳酸酐酶-II 显示出中 等活性。结果表明,S. pecten-veneris 具有良好的 药用潜力,可用于治疗一些特定的疾病。

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Authors and Affiliations

  1. Department of Chemistry, Islamia College University, Peshawar, 25120, KP, Pakistan

    Abdul Wahab & Hamayun Khan

  2. Biochemistry Section Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, KP, Pakistan

    Syed Aleem Jan, Zahid Khan, Fatima Syed & Muhammad Imran

  3. Department of Chemistry, University of Swabi, Anbar, 23561, KP, Pakistan

    Abdur Rauf

  4. Department of Botany, Islamia College University, Peshawar, 25120, KP, Pakistan

    Zia ur Rehman

  5. State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China

    Aftab Ahmed

  6. Interdisciplinary Research Center in Biomedical Materials, COMSATS Institute of Information Technology, Lahore, 54000, Pakistan

    Sher Zaman Safi

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  1. Abdul Wahab
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  2. Syed Aleem Jan
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  3. Abdur Rauf
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  4. Zia ur Rehman
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  5. Zahid Khan
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  7. Fatima Syed
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  8. Sher Zaman Safi
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  9. Hamayun Khan
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  10. Muhammad Imran
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Corresponding authors

Correspondence to Hamayun Khan or Muhammad Imran.

Additional information

Project supported by the Directorate of Science and Technology (DoST), Khyber Pakhtunkhwa, Pakistan, under Research Project Developmental Scheme (Bio-Tech Sector, Phase-1, A03959 Bio-Tech)

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Wahab, A., Jan, S.A., Rauf, A. et al. Phytochemical composition, biological potential and enzyme inhibition activity of Scandix pecten-veneris L.. J. Zhejiang Univ. Sci. B 19, 120–129 (2018). https://doi.org/10.1631/jzus.B1600443

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