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Transforming growth factor-β1 and disorders of the lung

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Abstract

The transforming growth factor (TGF) superfamily encompasses about 30 members in mammals. The effect of TGF-β subfamily members is exerted and regulated via selective pathways of synthesis and signaling that involve activation of latent TGF-β, specific and high-affinity binding to cell membrane serine/threonine kinase receptors, activation of intracellular cascades that include Smad molecules and mitogen-activated protein kinases, and regulated termination of the effect by diverse mechanisms including protein degradation and transcriptional activation. Several comprehensive reviews on TGF-β biology in general and on the role of this cytokine in other diseases have been published recently. In recent years an unexpected role of TGF-β on lung homeostasis has been revealed. Here, we discuss the contribution of TGF-β to the pathogenesis of asthma and chronic obstructive pulmonary disease, two common illnesses of the lung, as well as of lymphangioleiomyomatosis, a rare disease in women. The information we collate and integrate places TGF-β at a pivotal point within complex networks that control lung physiology as well as the physiopathology of these lung diseases.

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Authors and Affiliations

  1. Department of Medicine, The University of Chicago, 5841 S. Maryland Avenue, MC6026, Chicago, IL, 60637

    Blanca Camoretti-Mercado & Julian Solway

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  1. Blanca Camoretti-Mercado
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  2. Julian Solway
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Correspondence to Blanca Camoretti-Mercado.

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Camoretti-Mercado, B., Solway, J. Transforming growth factor-β1 and disorders of the lung. Cell Biochem Biophys 43, 131–148 (2005). https://doi.org/10.1385/CBB:43:1:131

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