Abstract
Bleomycin has, in the years of developing electrochemotherapy (ECT), proven to be an extremely potent drug for this cancer treatment modality and is also the most frequently applied chemical agent. It is of importance to investigate the pharmacokinetics of bleomycin under normal conditions and particularly in combination with ECT.
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References
Crooke, S. T. (1983) Pharmacokinetics of Anticancer Agents in Humans (Ames, M. M., Powis, G., and Kocach, J. S., eds.), Elsevier Science, Amsterdam, pp. 279–290.
Thakur, M. L. (1973) The preparation of indium-111 labelled bleomycin for tumor localisation. Int. J. Appl. Radiat. Isot. 24, 357–359.
Hou, D. Y., and Yosh, M. (1992) Distribution of 111In-bleomycin complex in small cell lung cancer cells by autoradiography. J. Surg. Oncol. 49, 93–97.
Hou, D. Y., Hoch, H., Johnston, G. S., Tsou, K. C., Farkas, R. J., and Miller, E. E. (1983) Stability of 111In-bleomycin in vivo: properties compared with 57Co-bleomycin. Eur. J. Nucl. Med. 8, 535–540.
Hou, D. Y., Hoch, H., Johnston, G. S., Tsou, K. C., Jones, A. E., Miller, E. E., and Larson, S. M. (1984) A new tumor imaging agent-111In-bleomycin complex: Comparison with 67-Ga-citrate and 57-Co-bleomycin in tumor-bearing animals. J. Surg. Oncol. 27, 189–195.
Siesjö, P., Visse, E., Lindvall, M., Salford, L. G., and Sjögren, H.-O. (1993) Immunization with mutagen-treated (tum-) cells causes rejection of nonimmunogenic rat glioma isografts. Cancer Immunol. Immunother. 37, 67–74.
Hou, D. Y., Hoch, H., Johnston, G. S., Tsou, K. C., Jones, A. E., Farkas, R. J., Miller, E. E., and Larson, S. M. (1985) A new 111-In-bleomycin complex for combined radiotherapy and chemotherapy. J. Surg. Oncol. 29, 91–98.
Woods, J. S. and Fowler, B. A. (1982) Selective inhibition of delta-aminolevulinic acid dehydratase by indium chloride in rat kidney: Biochemical and ultrastructural studies. Exp. Mol. Pathol. 36, 306–315.
Serša, G., Čemažar, M., and Miklavčič, D. (1995) Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res. 55, 3450–3455.
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© 2000 Humana Press Inc.
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Engström, P., Salford, L.G., Persson, B.R.R. (2000). Distribution of Bleomycin in a Rat Model. In: Jaroszeski, M.J., Heller, R., Gilbert, R. (eds) Electrochemotherapy, Electrogenetherapy, and Transdermal Drug Delivery. Methods in Molecular Medicine, vol 37. Humana Press. https://doi.org/10.1385/1-59259-080-2:285
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DOI: https://doi.org/10.1385/1-59259-080-2:285
Publisher Name: Humana Press
Print ISBN: 978-0-89603-606-2
Online ISBN: 978-1-59259-080-3
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