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Porous Inorganic Drug Delivery Systems—a Review

  • Review Article
  • Theme: Preparation of Nano and Micro-structures for Drug Delivery
  • Published:
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Abstract

Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures, marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (antibiotics, anticancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.

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ACKNOWLEDGMENTS

The authors would like to thank Minia University represented by Egyptian Culture Centre and Educational Bureau in London. The authors would also like to thank the EPSRC (EPSRC EHDA Network) for their support.

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Authors and Affiliations

  1. Leicester School of Pharmacy, De Montfort University, Leicester, LE1 9BH, UK

    E. Sayed, R. Haj-Ahmad, K. Ruparelia & Z. Ahmad

  2. Department of Pharmaceutical Technology, Faculty of Pharmacy, Minia University, Minia, Egypt

    E. Sayed

  3. Department of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan

    M. S. Arshad

  4. College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, 310027, China

    M.-W. Chang

  5. Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou, 310027, China

    M.-W. Chang

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  1. E. Sayed
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  4. M. S. Arshad
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Correspondence to Z. Ahmad.

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Guest Editors: Dr. Z Ahmad and Prof. M Edirisinghe

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Sayed, E., Haj-Ahmad, R., Ruparelia, K. et al. Porous Inorganic Drug Delivery Systems—a Review. AAPS PharmSciTech 18, 1507–1525 (2017). https://doi.org/10.1208/s12249-017-0740-2

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