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Terminalia Gum as a Directly Compressible Excipient for Controlled Drug Delivery

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ABSTRACT

The exudates from the incised trunk of Terminalia randii has been evaluated as controlled release excipient in comparison with xanthan gum and hydroxypropylmethylcellulose (HPMC) using carvedilol (water insoluble) and theophylline (water soluble) as model drugs. Matrix tablets were prepared by direct compression and the effects of polymer concentration and excipients—spray dried lactose, microcrystalline cellulose and dicalcium phosphate dihydrate on the mechanical (crushing strength (CS) friability (F) and crushing strength–friability ratio (CSFR)) and drug release properties of the matrix tablets were evaluated. The drug release data were fitted into different release kinetics equations to determine the drug release mechanism(s) from the matrix tablets. The results showed that the CS and CSFR increased with increase in polymer concentration while F decreased. The ranking of CS and CSFR was HPMC > terminalia > xanthan while the ranking was reverse for F. The ranking for t 25 (i.e. time for 25% drug release) at a polymer concentration of 60% was xanthan > terminalia = HPMC. The dissolution time, t 25, of theophylline matrices was significantly lower (p < 0.001) than those of carvedilol matrix tablets. Drug release from the matrices was by swelling, diffusion and erosion. The mechanical and drug release properties of the tablets were significantly (p < 0.05) dependent on the type and concentration of polymer and excipients used with the release mechanisms varying from Fickian to anomalous. Terminalia gum compared favourably with standard polymers when used in controlled release matrices and could serve as a suitable alternative to the standard polymers in drug delivery.

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References

  1. Talukdar MM, Kinget R. Swelling and drug release behaviour of xanthan gum matrix tablets. Int J Pharm. 1995;120:63–72.

    Article  CAS  Google Scholar 

  2. Sujja-areevath J, Munday DL, Cox PJ, Khan KA. Release characteristics of diclofenac sodium from encapsulated natural gum mini-matrix formulations. Int J Pharm. 1996;139:53–62.

    Article  CAS  Google Scholar 

  3. Cox PJ, Khan KA, Munday D, Sujja-areevath J. Development and evaluation of a multiple-unit oral sustained release dosage form from S (+)-ibuprofen: preparation and release kinetics. Int J Pharm. 1999;193:74–84.

    Article  Google Scholar 

  4. Odeku OA, Fell JT. Evaluation of khaya gum as directly compressible matrix system for controlled release. J Pharm Pharmacol. 2004;56(11):1365–70.

    Article  PubMed  CAS  Google Scholar 

  5. Odeku OA, Fell JT. Effects of the method of preparation on the compression, mechanical and release properties of khaya gum matrices. Pharm Dev Tech. 2006;11(4):435–41.

    Article  CAS  Google Scholar 

  6. Biswas BK, Islam MDS, Begum F, Rouf AS. In vitro release kinetic study of esomeprazole magnesium from methocel K15M and methocel K100 LVCR matrix tablets. Dhaka Univ J Pharm Sci. 2008;7(1):39–45.

    Google Scholar 

  7. Korsemeyer RW, Gurny R, Doelker EM, Buri P, Peppas NA. Mechanism of solute release from porous hydrophilic polymers. Int J Pharm. 1983;15:25–35.

    Article  Google Scholar 

  8. Shanmugasundaram S, Dhandapani NV, Rajendran A, Kumaraswamy S, Bhojraj S. Formulation of sodium alginate nanospheres containing amphotericin B for the treatment of systemic candidiasis. Trop J Pharm Res. 2007;6(1):653–9.

    Google Scholar 

  9. Ford JL, Rubenstein MH, McCaul F, Hogan JE, Edger PJ. Importance of drug type, tablet shape and added diluents on drug release kinetics from hydroxypropylmethylcellulose matrix tablets. Int J Pharm. 1987;40:223–34.

    Article  CAS  Google Scholar 

  10. Bamiro OA, Sinha VR, Kumar R, Odeku OA. Characterization and evaluation of Terminalia randii gum as a binder in carvedilol tablet formulation. Acta Pharm Sci. 2010;52:254–62.

    CAS  Google Scholar 

  11. Anderson DMW, Bell PC. The composition and properties of the gum exudates from Terminalia sericea and T. superba. Phytochem. 1974;13(9):1871–4.

    Article  CAS  Google Scholar 

  12. Efentakis M, Vlachou M, Choulis NH. Effects of excipients on swelling and drug release from compressed matrices. Drug Dev Ind Pharm. 1997;23:107–12.

    Article  CAS  Google Scholar 

  13. Wagner JG. Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules. J Pharm Sci. 1969;58(10):1253–7.

    Article  PubMed  CAS  Google Scholar 

  14. Gibaldi M, Feldman S. Establishment of sink conditions in dissolution rate determinations—theoretical considerations and application to non disintegrating dosage forms. J Pharm Sci. 1967;56(10):1238–42.

    Article  PubMed  CAS  Google Scholar 

  15. Higuchi T. Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci. 1961;50(10):874–5.

    Article  PubMed  CAS  Google Scholar 

  16. Hixson AW, Crowell JH. Dependence of reaction velocity upon surface and agitation. Ind Eng Chem. 1931;23:923–31.

    Article  CAS  Google Scholar 

  17. Costa P, Lobo JMS. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13:123–33.

    Article  PubMed  CAS  Google Scholar 

  18. British Pharmacopoeia. 2004; Her Majesty Stationary Office, London, UK

  19. Odeku OA, Itiola OA. Evaluation of the effects of khaya gum on the mechanical properties and release properties of paracetamol tablets. Drug Dev Ind Pharm. 2003;29:311–20.

    Article  PubMed  CAS  Google Scholar 

  20. Khurahashi H, Kami H, Sunada H. Influence of physicochemical properties on drug release rate from hydroxypropylmethylcellulose matrices. Chem Pharm Bull. 1996;44:829–32.

    Article  Google Scholar 

  21. Sandip BT, Krishna MT, Raveendra PM, Mehta PR, Chowdary PB. Controlled release formulation of tramadol hydrochloride using hydro-philic and hydrophobic matrix system. AAPS PharmSciTech 2003; 4 (3): Article 31.

    Google Scholar 

  22. Jivraj M, Martini LG, Thomson CM. An overview of different excipients useful for direct compression of tablets. Pharm Sci Tech Today. 2000;3:58–63.

    Article  CAS  Google Scholar 

  23. Bayomi MA, Al-Suwayeh SA, El-Helw AM. Excipient-excipient interaction in the design of sustained-release theophylline tablets: in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2001;27(6):499–506.

    Article  PubMed  CAS  Google Scholar 

  24. Shah VP, Tsong Y, Sathe P. In vitro dissolution profile comparison—statistics and analysis of the similarity factor f2. Pharm Res. 1998;15:880–96.

    Google Scholar 

  25. Reynolds TD, Gehrke SH, Hussain AS, Shenouda LS. Polymer erosion and drug release characterization of hydroxypropylmethylcellulose matrices. J Pharm Sci. 1998;87(9):1115–23.

    Article  PubMed  CAS  Google Scholar 

  26. Lee PL, Kim CJ. Probing the mechanism of drug release from hydrogels. J Control Rel. 1991;16:229–36.

    Article  CAS  Google Scholar 

  27. Barakat NS, Elbagory IM, Almurshedi AS. Controlled-release carbamazepine matrix granules and tablets comprising lipophilic and hydrophilic components. Drug Deliv. 2009;16(1):57–65.

    Article  PubMed  CAS  Google Scholar 

  28. Colombo P, Santi P, Bettini R, Brazel CS, Peppas NA. Drug release from swelling-controlled systems. In: Wise DL, editor. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker; 2000. p. 183–209.

    Google Scholar 

  29. Mutalik S, Naha A, Usha AN, Ranjith AK, Musmade P, Manoj K, et al. Preparation, in vitro, preclinical and clinical evaluations of once daily sustained release tablets of aceclofenac. Archiv Pharmacal Res. 2007;30(2):222–34.

    Article  CAS  Google Scholar 

  30. Russo LI, Ghaly ES. Drug release from Carbopol 934 matrices. P R Health Sci J. 2002;19:131–7.

    Google Scholar 

  31. Colombo P. Swelling-controlled release in hydrogel matrices for oral route. Adv Drug Del Rev. 1993;11:37–57.

    Article  CAS  Google Scholar 

  32. Williams RO, Reynolds TD, Cabelka TD, Sykora MA, Mahaguna V. Investigation of excipient type and level on drug release from controlled release tablets containing HPMC. Pharm Dev Technol. 2002;7(2):181–93.

    Article  PubMed  CAS  Google Scholar 

  33. Jamzad S, Tutunji L, Fassihi R. Analysis of macromolecular changes and drug release from hydrophilic matrix systems. Int J Pharm. 2005;292:75–85.

    Article  PubMed  CAS  Google Scholar 

  34. Rajesh KS, Venkataraju MP, Gowda DV. Effect of hydrophilic natural gums in formulation of oral controlled release matrix tablets of propanolol. Pak J Pharm Sci. 2009;22(2):211–9.

    PubMed  CAS  Google Scholar 

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ACKNOWLEDGEMENTS

We wish to acknowledge the India Science Academy for an INSA-TATA Fellowship awarded to O. A. Bamiro. We also thank Daman Ghai, Honey Goel and Gupreet Singh for their assistance during the study.

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Authors and Affiliations

  1. Department of Pharmaceutics and Pharmaceutical Technology, Olabisi Onabanjo University, Sagamu, Nigeria

    Oluyemisi A. Bamiro

  2. Department of Pharmaceutics and Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria

    Oluwatoyin A. Odeku

  3. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Vivek R. Sinha & Ruchita Kumar

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  1. Oluyemisi A. Bamiro
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  2. Oluwatoyin A. Odeku
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  3. Vivek R. Sinha
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  4. Ruchita Kumar
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Correspondence to Oluwatoyin A. Odeku.

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Bamiro, O.A., Odeku, O.A., Sinha, V.R. et al. Terminalia Gum as a Directly Compressible Excipient for Controlled Drug Delivery. AAPS PharmSciTech 13, 16–23 (2012). https://doi.org/10.1208/s12249-011-9712-0

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  • DOI: https://doi.org/10.1208/s12249-011-9712-0

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