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Wax-incorporated Emulsion Gel Beads of Calcium Pectinate for Intragastric Floating Drug Delivery

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Abstract

The purpose of this study was to prepare wax-incorporated pectin-based emulsion gel beads using a modified emulsion-gelation method. The waxes in pectin–olive oil mixtures containing a model drug, metronidazole, were hot-melted, homogenized and then extruded into calcium chloride solution. The beads formed were separated, washed with distilled water and dried for 12 h. The influence of various types and amounts of wax on floating and drug release behavior of emulsion gel beads of calcium pectinate was investigated. The drug-loaded gel beads were found to float on simulated gastric fluid if the sufficient amount of oil was used. Incorporation of wax into the emulsion gel beads affected the drug release. Water-soluble wax (i.e. polyethylene glycol) increased the drug release while other water-insoluble waxes (i.e. glyceryl monostearate, stearyl alcohol, carnauba wax, spermaceti wax and white wax) significantly retarded the drug release. Different waxes had a slight effect on the drug release. However, the increased amount of incorporated wax in the formulations significantly sustained the drug release while the beads remained floating. The results suggest that wax-incorporated emulsion gel beads could be used as a carrier for intragastric floating drug delivery.

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ACKNOWLEDGEMENTS

The authors thank K. Kuakoon for laboratory assistance and Food & Cosmetic System Co., Ltd. (Thailand) for supplying pectin samples manufactured by CP Kelco (Denmark). Financial support from Faculty of Pharmacy, Silpakorn University is greatly appreciated.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Pornsak Sriamornsak, Panida Asavapichayont, Jurairat Nunthanid, Manee Luangtana-anan, Sontaya Limmatvapirat & Suchada Piriyaprasarth

  2. Pharmaceutical Biopolymer Group (PBiG), Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, 73000, Thailand

    Pornsak Sriamornsak, Panida Asavapichayont, Jurairat Nunthanid, Manee Luangtana-anan, Sontaya Limmatvapirat & Suchada Piriyaprasarth

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  1. Pornsak Sriamornsak
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  2. Panida Asavapichayont
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  3. Jurairat Nunthanid
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  4. Manee Luangtana-anan
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  5. Sontaya Limmatvapirat
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  6. Suchada Piriyaprasarth
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Correspondence to Pornsak Sriamornsak.

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Sriamornsak, P., Asavapichayont, P., Nunthanid, J. et al. Wax-incorporated Emulsion Gel Beads of Calcium Pectinate for Intragastric Floating Drug Delivery. AAPS PharmSciTech 9, 571–576 (2008). https://doi.org/10.1208/s12249-008-9082-4

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  • DOI: https://doi.org/10.1208/s12249-008-9082-4

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