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Glycemic response of volunteers to the consumption of supplements and food formulas for oral and/or enteral nutrition

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Abstract

Purpose

The objective of this study was to determine the glycemic index (GI) and glycemic load (GL) of three products from the Brazilian market used as a supplement and food formula for oral and/or enteral nutrition.

Methods

The volunteers (n = 16) attended Food Research Center weekly for six weeks after a 10–12-h overnight fasting. Blood was sampled in the fasting state (t = 0) and at 15 min, 30 min, 45 min, 60 min, 90 min, and 120 min after starting to eat each evaluated meal: glucose solution (reference food, three times) and three products: Cubitan® vanilla (specific for wounds healing), Diasip® chocolate, and Diasip® vanilla (diabetic supplements). GI was determined by calculating the area under the glycemic response curve using the trapezoidal rule and ignoring the areas below the fasting line and considering the GI of glucose to be 100. To determine GL, it was considered the amount of carbohydrates available in a standard serving of the product and GI.

Results

The three products studied showed low GI and low GL (Cubitan® GI = 35, GL = 6; Diasip® chocolate GI = 49, GL = 7; Diasip® vanilla GI = 47, GL = 7), with significant differences from those and the reference food, but no significant difference between them. Similar results were also observed for the blood glucose peak, which occurred 30 min after the consumption of all products.

Conclusions

GI and GL of the products were considerably lower than those of the reference food. The products evaluated presented a low glycemic response, shown by a glycemic response curve with a slightly accentuated shape and no high peaks.

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Data availability

Datasets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request and with authorization from the sponsor company.

Abbreviations

GI :

Glycemic index

GL :

Glycemic load

AUC :

Area under the curve

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Acknowledgements

We thank all the volunteers who participated in the clinical trial and contributed with their time and goodwill.

Funding

Danone Brazil Ltda.

Author information

Authors and Affiliations

  1. Food Research Center (FoRC), Universidade de São Paulo, São Paulo, Brazil

    Eliana Bistriche Giuntini

  2. Danone Brazil LTDA, Medical Affairs Department, São Paulo, Brazil

    Giovanna Albuquerque Ruffo, Camila Leonel Mendes de Abreu, Marina Campos Russo, Jady Aléxia de Andrade Vidal & Mariana Vilela Rocha

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  1. Eliana Bistriche Giuntini
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Contributions

E.B.G. conceived and designed the study and participated in the data collection and analysis of the results. E.B.G., J.A.A.V., G.A.R., M.V.R., C.L.M.A., and M.C.R. participated in the drafting of the article and the critical review. All authors reviewed the manuscript and agreed to its final version.

Corresponding author

Correspondence to Eliana Bistriche Giuntini.

Ethics declarations

Ethics approval and consent to participate

Approval CEP/FCF 2.814.784 was granted by the Ethics Committee of the Faculty of Pharmaceutical Sciences.

Consent for publication

Not applicable.

Competing interests

G.A.R., C.L.M.A., M.C.R., J.A.A.V., and M.V.R. are employees of Danone Brazil Ltda. G.A.R and C.L.M.A. work in the Evidence Generation Department, and M.C.R., J.A.A.V., and M.V.R. work in the Medical Affairs Department. EBG (Researcher at FoRC) declares that there is no conflict of interest with the products used in this research.

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Giuntini, E.B., Ruffo, G.A., de Abreu, C.L.M. et al. Glycemic response of volunteers to the consumption of supplements and food formulas for oral and/or enteral nutrition. Nutrire 47, 32 (2022). https://doi.org/10.1186/s41110-022-00182-8

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