One important barrier to cancer immunotherapy. We used cyclic dinucleotides (CDNs) and Listeria vaccine and LPS treated HA-specific CD8 tolerance B10. D2 mice. Our results demonstrated T cells IFN-gamma increased in CDNs and Listeria vaccine plus CDNs treatment groups. But CDNs didn't significantly increase Treg cells. The data showed CDNs can reverse established T cell tolerance that improved cancer immunotherapy in the future. We will further explore T cells tolerance in cancer bearing T cell tolerance mice model in vivo.
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Fu, J., Kim, Y., Kanne, D. et al. Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy. j. immunotherapy cancer 3 (Suppl 2), P268 (2015). https://doi.org/10.1186/2051-1426-3-S2-P268
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DOI: https://doi.org/10.1186/2051-1426-3-S2-P268