Abstract
Posttraumatic knee osteoarthritis patients (n = 117) and healthy individuals (n = 94) were investigated to determine the genotype and allelic frequency distribution of polymorphic loci Т-31С, С + 3953Т IL-1β and G-308A TNF-α. The plasma and synovial fluid levels of proinflammatory cytokines IL-1β and TNF-α were also measured in 31 patients. The study demonstrated that the plasma and synovial fluid levels of IL-1β but not TNF-α were increased in patients with posttraumatic knee osteoarthritis. Also, the linkage between TNF-α levels and polymorphic locus G-308A TNF-α was shown: the presence of allele–308А was associated with decreased TNF-α levels. It was found that polymorphic loci Т-31С, С+3953Т IL-1β, and G-308A TNF-α are not markers of predisposition to posttraumatic knee osteoarthritis in Russian population of Rostov Oblast.
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Original Russian Text © V.V. Vnukov, I.V. Krolevets, S.B. Panina, N.P. Milutina, A.A. Ananyan, A.B. Sagakyants, M.A. Zabrodin, 2016, published in Uspekhi Gerontologii, 2016, Vol. 29, No. 1, pp. 52–58.
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Vnukov, V.V., Krolevets, I.V., Panina, S.B. et al. Gene polymorphism and levels of pro-inflammatory cytokines in plasma and synovial fluid of patients with posttraumatic knee osteoarthritis. Adv Gerontol 6, 198–203 (2016). https://doi.org/10.1134/S2079057016030152
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DOI: https://doi.org/10.1134/S2079057016030152