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Prospects for the Use of Gene Expression Analysis in Rheumatology

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Abstract—

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology, characterized by disturbances in functioning of immune system signaling pathways. This is accompanied by injury of other tissues, pain and joint destruction. Modern treatment is aimed at correction of pathophysiological and biochemical mechanisms responsible for clinical manifestation of the disease. However, due to heterogeneity of RA patients there is a clear need in the personalized approach to the RA treatment; the choice of personalized treatment is complicated by the variability of RA patient responses to the therapy. Gene expression analysis may serve as a tool for the disease control and therapy personification, for inhibition of inflammation and pain as well as for prevention of joint destruction.

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  1. Nasonova Research Institute of Rheumatology, Kashirskoe shosse 34A, 115522, Moscow, Russia

    E. V. Chetina & G. A. Markova

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Chetina, E.V., Markova, G.A. Prospects for the Use of Gene Expression Analysis in Rheumatology. Biochem. Moscow Suppl. Ser. B 13, 13–25 (2019). https://doi.org/10.1134/S1990750819010049

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