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Synthesis of water soluble quaternary chitosan derivative via protection-deprotection strategy and investigation of its antibacterial effect

  • Medical Polymers
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Abstract

New water-soluble trimethyl quaternary derivative of chitosan was synthesized by a multi step processes through protection-deprotection strategy. This derivative was characterized using FTIR and 1H NMR spectroscopy. Finally, the antibacterial effect of this derivative against Gram-negative (Escherichia coli and Salmonella typhimurium) and Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) bacteria in acidic and nutral medium was invetigated. The results of this study demonstrated that this chitosan derivative did not have antibacterial activity against Gram-negative bacteria; however, it showed a relatively good antibacterical effect against Gram-positive bacteria in both acidic and neutral mediums.

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Authors and Affiliations

  1. Department of Chemistry, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

    Farzad Seidi & Parvin Heshmati

  2. Department of Biochemistry, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran

    Samira Galehdari

  3. Medical Biology Research Center, University of Medical Sciences, Kermanshah, Iran

    Ahmad Tajehmiri

  4. Standard Research Institute (SRI), Karaj, 31745-139, Iran

    Hamid Salimi

Authors
  1. Farzad Seidi
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  2. Parvin Heshmati
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  3. Samira Galehdari
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  4. Ahmad Tajehmiri
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  5. Hamid Salimi
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Correspondence to Farzad Seidi.

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Seidi, F., Heshmati, P., Galehdari, S. et al. Synthesis of water soluble quaternary chitosan derivative via protection-deprotection strategy and investigation of its antibacterial effect. Polym. Sci. Ser. B 58, 341–346 (2016). https://doi.org/10.1134/S1560090416030143

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  • DOI: https://doi.org/10.1134/S1560090416030143

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