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Study of 90Y Sorption with Nanodiamonds as Potential Carriers in the Radiopharmaceutical Composition

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Radiochemistry Aims and scope

Abstract

The sorption of 90Y with nanodiamond (ND) and oxidized nanodiamond (oxND) was studied for their subsequent application as part of radiopharmaceuticals for β-therapy in nuclear medicine. The sorption kinetics was studied as a function of pH and salt background of aqueous solutions. It was found that the optimal media for 90Y sorption are aqueous solutions with pH from 5 to 7, as well as 0.9% NaCl solution and phosphate-buffered saline therewith as shown the presence of a salt background has no significant effect on sorption. The study of the stability of 90Y conjugates with ND and oxND in a model biological medium (fetal bovin serum) demonstrated that desorption does not exceed 27% in 24 h for the studied ND samples.

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Funding

The study was supported by a grant from the Russian Science Foundation (project no. 18-13-00413).

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Authors and Affiliations

  1. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    A. G. Kazakov, J. S. Babenya, M. K. Ivanova, S. E. Vinokurov & B. F. Myasoedov

  2. Interdepartmental Center of Analytical Research in Physics, Chemistry and Biology, Russian Academy of Sciences, 117997, Moscow, Russia

    B. F. Myasoedov

Authors
  1. A. G. Kazakov
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  2. J. S. Babenya
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  3. M. K. Ivanova
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  4. S. E. Vinokurov
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  5. B. F. Myasoedov
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Correspondence to A. G. Kazakov.

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Additional information

Translated from Radiokhimiya, No. 1, pp. 60–64, April, 2022 https://doi.org/10.31857/S0033831122010051

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Kazakov, A.G., Babenya, J.S., Ivanova, M.K. et al. Study of 90Y Sorption with Nanodiamonds as Potential Carriers in the Radiopharmaceutical Composition. Radiochemistry 64, 44–48 (2022). https://doi.org/10.1134/S1066362222010076

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