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Effect of the Molecular Mass of Hyaluronan on Its Thermophysical Properties and on Dynamic Viscosity of Its Aqueous Solutions

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Abstract

The effect of the molecular mass of hyaluronans on the thermophysical and rheoviscometric properties of samples based on them has been studied. Differential scanning calorimetry revealed exothermic effects associated with the thermal degradation of these polysaccharides. The relationship between the area of the high-temperature degradation peak at 245–248°C and the molecular mass of polymeric hyaluronans has been determined, whereas this peak is absent for oligomeric hyaluronans with M < 6.6 × 103. A rheoviscometric study has shown that the flow of aqueous solutions of hyaluronans at low concentrations is close to Newtonian. The relationship between the viscosity of the solution and the molecular mass of polymeric hyaluronans (M > 50 × 103) has been established, and methods for rapid assessment of the hyaluronan molecular mass have been proposed.

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Authors and Affiliations

  1. MIREA—Russian Technological University, 119571, Moscow, Russia

    E. G. Li, E. O. Morenko, E. S. Zhavoronok, A. V. Panov & S. A. Kedik

  2. Institute of Pharmaceutical Technologies, 121353, Moscow, Russia

    A. V. Panov & S. A. Kedik

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  1. E. G. Li
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  2. E. O. Morenko
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Correspondence to E. S. Zhavoronok.

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Translated by S. Zatonsky

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Li, E.G., Morenko, E.O., Zhavoronok, E.S. et al. Effect of the Molecular Mass of Hyaluronan on Its Thermophysical Properties and on Dynamic Viscosity of Its Aqueous Solutions. Polym. Sci. Ser. A 64, 467–475 (2022). https://doi.org/10.1134/S0965545X22700249

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