Abstract
The level of proinflammatory markers was assessed in HIV-infected patients that were coinfected with hepatitis C virus (HCV) and had failed to restore the CD4+ T cell counts (immunological nonresponders, INR) during the antiretroviral therapy (ART). Among four patient groups (HIV+HCV– and HIV+HCV+ subjects with the concordant response to ART; HIV+HCV– and HIV+HCV+ subjects that were INR), the greatest systemic inflammation was in the latter group. The maximum difference was between the subjects HIV+HCV–INR and HIV+HCV+ INR: the blood of coinfected patients contained significantly higher concentrations of the IP-10, sCD163, sTNF-RI, and sTNF-RII and of bacterial lipopolysaccharide. Systemic inflammation in HIV/HCV coinfected patients with the discordant response to ART is probably caused by a breach of hepatic barrier for the intestine products.
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Original Russian Text © K.V. Shmagel, L.B. Korolevskaya, E.V. Saidakova, N.G. Shmagel, V.A. Chereshnev, L. Margolis, D. Anthony, M. Lederman, 2017, published in Doklady Akademii Nauk, 2017, Vol. 477, No. 2, pp. 253–256.
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Shmagel, K.V., Korolevskaya, L.B., Saidakova, E.V. et al. HCV coinfection of the HIV-infected patients with discordant CD4+ T-cell response to antiretroviral therapy leads to intense systemic inflammation. Dokl Biol Sci 477, 244–247 (2017). https://doi.org/10.1134/S0012496617060047
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DOI: https://doi.org/10.1134/S0012496617060047