Skip to main content
SpringerLink
Log in

Effect of 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic and Arachidonic Acids on Differentiation of Neurospora crassa

  • Published:
Applied Biochemistry and Microbiology Aims and scope Submit manuscript

Abstract

Comparative analysis of the influence of arachidonic acid and its derivatives, 3-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic and 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic acids, on the formation of sexual and asexual reproductive structures in Neurospora crassa demonstrated that the presence and location of the hydroxyl group in unsaturated fatty acid determine the biological effect of the compound. In the presence of 5 μM of arachidonic acid, 20-HETE, and 3-HETE, vegetative spore formation in the light decreased by 45, 31, and 40%, respectively, indicating a similarity in the mechanisms of their action on the light-dependent asexual reproduction of the fungus. However, the effects of these compounds on the sexual process of N. crassa were radically different. Gas chromatography–mass spectrometry (GC–MS) revealed a fourfold increase in the monounsaturated oleic acid content in N. crassa cells after the addition of arachidonic acid. In the same time, the effect was not observed after the addition of 20-HETE. On the other hand, the increase in the linoleic acid content in the fungal mycelia was higher with 20-HETE.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gessler, N.N., Filippovich, S.Yu., Bachurina, G.P., Kharchenko, E.A., Groza, N.V., and Belozerskaya, T.A., Appl. Biochem. Microbiol., 2017, vol. 53, no. 6, pp. 628–639.

    Article  CAS  Google Scholar 

  2. Calvo, A.M., Hinze, L.L., Gardner, H.W., and Keller, N.P., Appl. Environ. Microbiol., 1999, vol. 65, no. 8, pp. 3668–3673.

    PubMed  PubMed Central  CAS  Google Scholar 

  3. Katayama, M. and Marumo, S., Agric. Biol. Chem., 1978, vol. 42, no. 7, pp. 1431–1433.

    CAS  Google Scholar 

  4. Gessler, N.N., Filippovich, S.Yu., Bachurina, G.P., Groza, N.V., Dorodnikova, E.A., and Belozerskaya, T.A., Microbiology (Moscow), 2012, vol. 81, no. 5, pp. 542–548.

    Article  CAS  Google Scholar 

  5. Filippovich, S.Yu., Bachurina, G.P., Gessler, N.N., Golovanov, A.B., Makarova, A.M., Groza, N.V., and Belozerskaya, T.A., Appl. Biochem. Microbiol., 2015, vol. 51, no. 6, pp. 655–659.

    Article  CAS  Google Scholar 

  6. Williams, J.M., Murphy, S., Burke, M., and Roman, R.J., J. Cardiovasc. Pharmacol., 2010, vol. 56, no. 4, pp. 336–344.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. Alexanian, A., Rufanova, V.A., Miller, B., Flasch, A., Roman, R.J., and Sorokin, A., Anticancer Res., 2009, vol. 29, no. 10, pp. 3819–3824.

    PubMed  PubMed Central  CAS  Google Scholar 

  8. Hoff, U., Lukitsch, I., Chaykovska, L., Ladwig, M., Arnold, C., Manthati, V.L., et al., Kidney Int., 2011, vol. 79, no. 1, pp. 57–65.

    Article  PubMed  CAS  Google Scholar 

  9. Ge, Y., Murphy, S.R., Lu, Y., Falck, J., Liu, R., and Roman, R.J., Prostaglandins Other Lipid Mediat., 2013, vol. 102–103, pp. 42–48.

    Article  PubMed  CAS  Google Scholar 

  10. Hwang, S.H., Wagner, K., Xu, J., Yang, J., Li, X., Cao, Z., et al., Bioorg. Med. Chem. Lett., 2017, vol. 27, no. 3, pp. 620–625.

    Article  PubMed  CAS  Google Scholar 

  11. Kritskii, M.S., Belozerskaya, T.A., Sokolovskii, V.Yu., and Filippovich, S.Yu., Mol. Biol., 2005, vol. 39, no. 4, pp. 602–617.

    CAS  Google Scholar 

  12. Klemm, E. and Ninneman, H., Photochem. Photobiol., 1978, vol. 28, no. 2, pp. 227–230.

    Article  Google Scholar 

  13. Degli-Innocenti, F., Pohl, U., and Russo, V.E.A., Photochem. Photobiol., 1983, vol. 37, no. 1, pp. 49–51.

    Article  Google Scholar 

  14. Filippovich, S.Yu., Bachurina, G.P., and Shcherbakov, D.L., Appl. Biochem. Microbiol., 2015, vol. 51, no. 3, pp. 342–349.

    Article  CAS  Google Scholar 

  15. Groza, N.V., Ivanov, I.V., Golovanov, A.B., and Myagkova, G.I., Vestnik MITKhT, 2006, vol. 1, no. 4, pp. 29–32.

    Google Scholar 

  16. Golovanov, A.B., Groza, N.V., and Myagkova, G.I., Vestnik MITKhT, 2012, vol. 7, no. 5, pp. 23–27.

    CAS  Google Scholar 

  17. Davis, R.V. and de Serres, F.J., Methods Enzymol., 1970, vol. 17, pp. 79–143.

    Article  Google Scholar 

  18. Smith, G., Bioanalysis, 2010, vol. 2, pp. 929–935.

    Article  PubMed  CAS  Google Scholar 

  19. Groza, N.V., Ivanov, I.V., Romanov, S.G., Myagkova, G.I., and Nigam, S., Tetrahedron, 2002, vol. 58, pp. 9859–9863.

    Article  CAS  Google Scholar 

  20. Romanov, S.G., Ivanov, I.V., Groza, N.V., Kuhn, H., and Myagkova, G.I., Tetrahedron, 2002, vol. 58, pp. 8483–8487.

    Article  CAS  Google Scholar 

  21. Prabhune, A., Fox, S., and Ratledge, C., Biotechnol. Lett., 2002, vol. 24, pp. 1041–1044.

    Article  CAS  Google Scholar 

  22. Froehlich, A.C., Liu, Y., Loros, J.J., and Dunlap, J.C., Science, 2002, vol. 297, no. 5582, pp. 815–819.

    Article  PubMed  CAS  Google Scholar 

  23. He, Q., Cheng, P., Yang, Y., Wang, L., Gardner, K.H., and Liu, Y., Science, 2002, vol. 297, no. 5582, pp. 840–843.

    Article  PubMed  CAS  Google Scholar 

  24. Linden, H., Ballario, P., and Macino, G., Fungal. Genet. Biol., 1997, vol. 22, no. 3, pp. 141–150.

    Article  PubMed  CAS  Google Scholar 

  25. Bayram, O., Feussner, K., Dumkow, M., Herrfurth, C., Feussner, I., and Braus, G.H., Fungal Genet. Biol., 2016, vol. 87, no. 1, pp. 30–53.

    Article  PubMed  CAS  Google Scholar 

  26. Tsitsigiannis, D.I. and Keller, N.P., Trends Microbiol., 2007, vol. 15, no. 3, pp. 109–118.

    Article  PubMed  CAS  Google Scholar 

  27. Tsitsigiannis, D.I. and Keller, N.P., Mol. Microbiol., 2006, vol. 59, no. 3, pp. 882–892.

    Article  PubMed  CAS  Google Scholar 

  28. Hu, X., Li, H., Tang, P., Sun, J., Yuan, Q., and Li, C., Fungal. Genet. Biol., 2013, vol. 57, pp. 33–41.

    Article  PubMed  CAS  Google Scholar 

  29. Nukina, M., Sassa, T., Ikeda, M., and Takahashi, K., Agric. Biol. Chem., 1981, vol. 45, no. 10, pp. 2371–2373.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bach Institute of Biochemistry, Biotechnology Research Center, Russian Academy of Sciences, Moscow, 119071, Russia

    S. Yu. Filippovich, N. N. Gessler, G. P. Bachurina & T. A. Belozerskaya

  2. Moscow Technological University, Lomonosov Institute of Fine Chemical Technologies, Moscow, 119571, Russia

    E. A. Kharchenko, I. V. Ivanov, T. I. Sirotenko, A. B. Golovanov & N. V. Groza

Authors
  1. S. Yu. Filippovich
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. N. Gessler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. P. Bachurina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. E. A. Kharchenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. V. Ivanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T. I. Sirotenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. A. B. Golovanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T. A. Belozerskaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. N. V. Groza
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Yu. Filippovich.

Additional information

Original Russian Text © S.Yu. Filippovich, N.N. Gessler, G.P. Bachurina, E.A. Kharchenko, I.V. Ivanov, T.I. Sirotenko, A.B. Golovanov, T.A. Belozerskaya, N.V. Groza, 2018, published in Prikladnaya Biokhimiya i Mikrobiologiya, 2018, Vol. 54, No. 3, pp. 286–293.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Filippovich, S.Y., Gessler, N.N., Bachurina, G.P. et al. Effect of 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoic and Arachidonic Acids on Differentiation of Neurospora crassa. Appl Biochem Microbiol 54, 309–315 (2018). https://doi.org/10.1134/S0003683818030055

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0003683818030055

Keywords

Search

Navigation