Abstract
Results of histological and immunohistochemical studies of the nervous tissue of mongrel albino rats exposed to the influence of a nanobiocomposite containing silver nanoparticles and a natural biopolymer such as arabinogalactan for 9 days are under discussion. It is proved that both under acute exposure and in the survival period, the use of the examined substance leads to structural and functional changes in nervous tissue such as an increase in the number of hyperchromic cells, a creduction of the total number of cells per area unit, and the development of perivascular edema. The triggering of apoptosis of neurons of the brain manifested by a statistically significant increase in the number of cells which express caspase-3 pro-apoptotic protein is found. It is determined that silver nanoparticles encapsulated in a natural arabinogalactan polymer matrix penetrate the blood–brain barrier, thus causing long-term morphological and functional disturbances of the brain tissue in rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. H. Ji, Inhalat. Toxicol. 19 (10), 857–71 (2007).
M. C. Stensberg et al., Nanomedicine (London), No. 6, 879–898 (2011).
S. K. Sahoo, S. Parveen, and J. J. Panda, Nanomed.: Nanotechnol., Biol. Med., No. 3, 20 (2007).
N. Lewinski, V. Colvin, and R. Drezek, Small J. 4, 26 (2008).
A. B. G. Lansdown, Adv. Pharmacol. Sci. 10, 910686 (2010).
M. G. Shurygin et al., Nanomed.: Nanotechnol., Biol. Med. 7, 827–833 (2011).
K. Unfried, Nanotoxicology 1, 52–71 (2007).
M. Allsopp, A. Walters, and D. Santino, Preprint of Greenpeace Research Laboratories (2007).
G. F. Prozorova, A. S. Pozdnyakov, N. P. Kuznetsova, et al., Int. J. Nanomed., No. 9, 1883–1889 (2014).
V. I. Dubrovina and E. P. Golubinskii, et al., “Studing of ferrogale effect on protective properties of Yersinia pestis EV,” Sibir’-Vostok, No. 3, 8–9 (2002).
Patent RF No. 2256668 (2005); RZh Khim., 05/24- 19F.22P (2005).
V. I. Dubrovina, S. A. Medvedeva, et al., Immunomodulating Action of Arabinogalactan of Siberian Larch (Farmatsiya, Moscow, 2001), pp. 26–27 [in Russian].
E. N. Medvedeva, V. A. Babkin, and L. A. Ostroukhova, Khim. Rastit. Syr’ya, No. 1, 27 (2003).
M. A. Abdelhalim and B. M. Jarrar, J. Nanobiotechnol. 10, 5 (2012).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E.A. Titov, M.A. Novikov, L.M. Sosedova, 2015, published in Rossiiskie Nanotekhnologii, 2015, Vol. 10, Nos. 7–8.
Rights and permissions
About this article
Cite this article
Titov, E.A., Novikov, M.A. & Sosedova, L.M. Effect of silver nanoparticles encapsulated in a polymer matrix on the structure of nervous tissue and expression of caspase-3. Nanotechnol Russia 10, 640–644 (2015). https://doi.org/10.1134/S1995078015040205
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1995078015040205