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Synthesis and structure of [2-oxo(thioxo)tetrahydropyrimidin-4-yl]calix[4]arenes

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Abstract

Cone-shaped di- and tetrapropoxycalix[4]arenes functionalized at the upper rim with one or two 2-oxo(thioxo)tetrahydropyrimidine residues were synthesized by the Biginelli reaction of formylcalixarenes with urea (thiourea) and methyl acetoacetate. The steric structure of the products was studied by NMR and X-ray diffraction. The Biginelli reaction with dipropoxyformylcalixarene was diastereoselective, and it quantitatively produced the corresponding meso form. Tetrapropoxydiformylcalixarenes under analogous conditions gave rise to equimolar mixtures of racemic and meso compounds. The macrocyclic skeleton of the synthesized pyrimidine-containing calixarenes in crystal and in solution has a flattened cone conformation. (5-Methoxycarbonyl-2-oxotetrahydropyrimidin-4-yl)calixarene molecules in crystal undergo self-organization to form infinite chains via repeated inclusion of the methoxy group into the cavity of the neighboring macrocycle. Selforganization of bis(5-methoxycarbonyl-2-oxotetrahydropyrimidin-4-yl)calixarene with formation of analogous chains involves intermolecular hydrogen bonding NH ... O=C.

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Authors and Affiliations

  1. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, ul. Murmanskaya 5, Kiev, 02660, Ukraine

    S. G. Vishnevskii, A. B. Drapailo, A. V. Ruban, V. V. Pirozhenko & V. I. Kal’chenko

  2. Institute for Single Crystals, National Academy of Sciences of Ukraine, pr. Lenina 60, Kharkiv, 61001, Ukraine

    S. V. Shishkina & O. V. Shishkin

  3. Karazin Kharkiv National University, pl. Svobody 4, Kharkiv, 61022, Ukraine

    O. V. Shishkin

Authors
  1. S. G. Vishnevskii
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  2. A. B. Drapailo
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  3. A. V. Ruban
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  4. V. V. Pirozhenko
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  5. S. V. Shishkina
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  6. O. V. Shishkin
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  7. V. I. Kal’chenko
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Corresponding author

Correspondence to V. I. Kal’chenko.

Additional information

Original Russian Text © S.G. Vishnevskii, A.B. Drapailo, A.V. Ruban, V.V. Pirozhenko, S.V. Shishkina, O.V. Shishkin, V.I. Kal’chenko, 2014, published in Zhurnal Organicheskoi Khimii, 2014, Vol. 50, No. 4, pp. 582–591.

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Vishnevskii, S.G., Drapailo, A.B., Ruban, A.V. et al. Synthesis and structure of [2-oxo(thioxo)tetrahydropyrimidin-4-yl]calix[4]arenes. Russ J Org Chem 50, 571–580 (2014). https://doi.org/10.1134/S1070428014040228

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  • DOI: https://doi.org/10.1134/S1070428014040228

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