Skip to main content
SpringerLink
Log in

Anti-inflammatory activity of pectins and their galacturonan backbone

  • Plant Biopolymers
  • Published:
Russian Journal of Bioorganic Chemistry Aims and scope Submit manuscript

Abstract

It has been shown that pectin polysaccharides from different plants, depending on their structure, can either protect the intestinal walls of mammals against damage and inhibit the development of inflammation or, on the contrary, have proinflammatory effects. At the same time, galacturonan isolated from any pectin, being the main carbohydrate chain (backbone) of its macromolecule, shows a marked anti-inflammatory effect. A decrease in the quantity of neutrophiles in the intestinal wall after induced inflammation indicates that the anti-inflammatory effects of pectins can be based on their influence on the functional activity of leukocytes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Rolandelli, H.R., Saul, S.H., Settle, R.G., and Jacobs, D.O., Am. J. Clin. Nutr., 1988, vol. 47, pp. 715–721.

    PubMed  CAS  Google Scholar 

  2. Mao, Y., Kasravi, B., Nobaek, S., Wang, D., and Jeppsson, B., Scand. J. Gastroenterol., 1996, vol. 31, no. 6, pp. 558–567.

    Article  PubMed  CAS  Google Scholar 

  3. Liu, L., Wang, Z., Pan, B., and Zhou, S., Word. J. Gastroenterol., 2003, vol. 9, pp. 2284–2288.

    CAS  Google Scholar 

  4. Lim, B.O., Lee, S.H., and Choue, R.W., Biosci. Biotechnol. Biochem., 2003, vol. 67, no. 8, pp. 1706–1712.

    Article  PubMed  CAS  Google Scholar 

  5. Ovodov, Yu.S., Golovchenko, V.V., Gyunter, E.A., and Popov, S.V., Pektinovye veshchestva rastenii Evropeiskogo severa Rossii (Pectic Compounds of Plants of the European North of Russia), Yekaterinburg, 2009.

  6. Ovodova, R.G., Bushneva, O.A., Shashkov, A.S., and Ovodov, Yu.S., Russ. J. Bioorg. Chem., 2000, vol. 26, no. 9, pp. 616–622.

    CAS  Google Scholar 

  7. Ovodova, R.G., Golovchenko, V.V., Shashkov, A.S., Popov, S.V., and Ovodov, Yu.S., Russ. J. Bioorg. Chem., 2000, vol. 26, no. 10, pp. 669–676.

    Article  CAS  Google Scholar 

  8. Ovodova, R.G., Bushneva, O.A., Shashkov, A.S., Chizhov, A.O., and Ovodov, Biochemistry (Moscow), 2005, vol. 70, no. 8, pp. 867–877.

    Article  CAS  Google Scholar 

  9. Popov, S.V., Popova, G.Yu., Ovodova, R.G., and Ovodov, Yu.S., Fitoterapia, 2005, vol. 76, pp. 281–287.

    Article  PubMed  CAS  Google Scholar 

  10. Popov, S.V., Ovodova, R.G., and Ovodov, Yu.S., Phytother. Res., 2006, vol. 20, pp. 403–407.

    Article  PubMed  CAS  Google Scholar 

  11. Itoh, H., Kataoka, H., Tomita, M., Hamasuna, R., Nawa, Y., Kitamura, N., and Koono, M., Am. J. Physiol. Gastrointest. Liver. Physiol., 2000, vol. 278, p. 635.

    Google Scholar 

  12. Mahgoub, A., Toxicol. Lett., 2003, vol. 145, no. 1, pp. 79–87.

    Article  PubMed  CAS  Google Scholar 

  13. Pinegin, B.V., Butakov, A.A., and Chelkina, T.L., Ekologicheskaya immunologiya. Kompleks metodov dlya opredeleniya funktsional’noi aktivnosti fagotsitov (Ecological Immunology: A Complex of Methods for Determination of Functional Activity of Phagocytes), Khaitov, R.M., Pinegin, B.V., and Istamov, Kh.I., Eds., Moscow, 1995.

  14. Popov, S.V., Ovodova, R.G., Markov, P.A., Nikitina, I.R., and Ovodov, Yu.S., Dig. Dis. Sci., 2006, vol. 51, pp. 1532–1537.

    Article  PubMed  CAS  Google Scholar 

  15. Popov, S.V., Markov, P.A., Nikitina, I.R., Petrishev, S.V., Smirnov, V.V., and Ovodov, Yu.S., World J. Gastroenterol., 2006, vol. 41, pp. 6646–6651.

    Google Scholar 

  16. Popov, S.V., Vinter, V.G., Patova, O.A., Markov, P.A., Nikitina, I.R., Ovodova, R.G., Popova, G.Yu., Shashkov, A.S., and Ovodov, Yu.S., Biochemistry (Moscow), 2007, vol. 72, pp. 778–784.

    Article  CAS  Google Scholar 

  17. Ovodov, Yu.S., Russ. J. Bioorg. Chem., 2009, vol. 35, no. 3, pp. 269–284.

    Article  CAS  Google Scholar 

  18. Golovchenko, V.V., Ovodova, R.G., Shashkov, A.S., and Ovodov, Yu.S., Phytochemistry, 2002, vol. 60, pp. 89–97.

    Article  PubMed  CAS  Google Scholar 

  19. Golovchenko, V.V., Bushneva, O.A., Ovodova, R.G., Shashkov, A.S., Chizhov, A.O., and Ovodov, Yu.S., Russ. J. Bioorg. Chem., 2007, vol. 33, no. 1, pp. 47–56.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, Komi Research Center, Ural Branch, Russian Academy of Sciences, ul. Pervomaiskaya 50, Syktyvkar, 167982, Russia

    P. A. Markov, S. V. Popov, I. R. Nikitina, R. G. Ovodova & Yu. S. Ovodov

Authors
  1. P. A. Markov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. V. Popov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I. R. Nikitina
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. G. Ovodova
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu. S. Ovodov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. A. Markov.

Additional information

Original Russian Text © P.A. Markov, S.V. Popov, I.R. Nikitina, R.G. Ovodova, Yu.S. Ovodov, 2010, published in Khimija Rastitel’nogo Syr’ja, 2010, No. 1, pp. 21–26.

The article is recommended for publication by the Organizing Committee of Scientific and Practical Conference Dedicated to the 10th Anniversary of Foundation of the “Physicochemical Biology” Education and Research Center, Komi Republic.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Markov, P.A., Popov, S.V., Nikitina, I.R. et al. Anti-inflammatory activity of pectins and their galacturonan backbone. Russ J Bioorg Chem 37, 817–821 (2011). https://doi.org/10.1134/S1068162011070132

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1068162011070132

Keywords

Search

Navigation