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Preparation of high-purity 68Ga solutions by ion exchange in mixed acetone-hydrochloric acid medium

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Abstract

Ion-exchange behavior of 68Ga in the mixed HCl-acetone medium on cation and anion exchangers was studied. The equilibrium gravimetric distribution coefficients of 68Ga on Dowex AG 50W×8 strongly acidic cation exchanger in the H+ form and on Dowex AG 1×8 strongly basic anion exchanger in the Cl− form in mixed HCl-acetone solutions at HCl concentrations in the range 0.1–3 M and acetone volume fractions in the range 0–90% were determined. The dynamic characteristics of the 68Ga ion exchange in mixed HCl-acetone solutions were studied. A process based on the data obtained was developed for preparing 68Ga solutions in 0.1 MHCl of high chemical and radiochemical purity, suitable for producing 68Ga radiopharmaceuticals of required quality (radiochemical purity 98.1 ± 1.4%).

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Authors and Affiliations

  1. Burnazyan Federal Medical Biophysical Center, ul. Zhivopisnaya 46, Moscow, 123182, Russia

    A. A. Larenkov, A. B. Bruskin & G. E. Kodina

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  1. A. A. Larenkov
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  2. A. B. Bruskin
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  3. G. E. Kodina
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Correspondence to A. A. Larenkov.

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Original Russian Text © A.A. Larenkov, A.B. Bruskin, G.E. Kodina, 2014, published in Radiokhimiya, 2014, Vol. 56, No. 1, pp. 51–58.

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Larenkov, A.A., Bruskin, A.B. & Kodina, G.E. Preparation of high-purity 68Ga solutions by ion exchange in mixed acetone-hydrochloric acid medium. Radiochemistry 56, 57–65 (2014). https://doi.org/10.1134/S1066362214010123

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  • DOI: https://doi.org/10.1134/S1066362214010123

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